Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.
Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.
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DOI：
10.3389/fendo.2015.00030
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发表时间：
2015
影响因子：
5.2
通讯作者：
Maggiolini M
中科院分区：
文献类型：
--
作者：
De Marco P;Cirillo F;Vivacqua A;Malaguarnera R;Belfiore A;Maggiolini M
胰岛素/胰岛素样生长因子系统在癌症进展中起着重要作用。因此，循环胰岛素水平升高与癌症风险增加以及侵袭性和转移性癌症表型有关。大量研究表明，雌激素在多种病理生理条件下与胰岛素/胰岛素样生长因子系统协同作用。雌激素的生物学反应主要由雌激素受体(ER)α和ERβ作为转录因子介导，但最近的一些研究表明，G蛋白偶联受体中的一个成员，即G蛋白雌激素受体，也参与正常细胞、恶性肿瘤细胞和癌症相关成纤维细胞的雌激素信号转导。在这方面，最近已经证明了通过GPER将雌激素的作用与胰岛素/IGF系统联系起来的新机制。本文综述了胰岛素/胰岛素样生长因子和雌激素GPER信号转导通路之间的相互作用的相关方面，这些信号转导通路存在于不同类型的细胞中，可能是癌症进展的原因。
The insulin/IGF system plays an important role in cancer progression. Accordingly, elevated levels of circulating insulin have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes. Numerous studies have documented that estrogens cooperate with the insulin/IGF system in multiple pathophysiological conditions. The biological responses to estrogens are mainly mediated by the estrogen receptors (ER)α and ERβ, which act as transcription factors; however, several studies have recently demonstrated that a member of the G protein-coupled receptors, named GPR30/G-protein estrogen receptor (GPER), is also involved in the estrogen signaling in normal and malignant cells as well as in cancer-associated fibroblasts (CAFs). In this regard, novel mechanisms linking the action of estrogens through GPER with the insulin/IGF system have been recently demonstrated. This review recapitulates the relevant aspects of this functional cross-talk between the insulin/IGF and the estrogenic GPER transduction pathways, which occurs in various cell types and may account for cancer progression.
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影响因子：
3.8
作者：
Arias-Pulido, Hugo;Royce, Melanie;Gong, Yun;Joste, Nancy;Lomo, Lesley;Lee, Sang-Joon;Chaher, Nabila;Verschraegen, Claire;Lara, Juanita;Prossnitz, Eric R.;Cristofanilli, Massimo
通讯作者：
Cristofanilli, Massimo
影响因子：
8
作者：
De Marco, P.;Bartella, V.;Maggiolini, M.
通讯作者：
Maggiolini, M.
影响因子：
3.9
作者：
Belfiore, A;Pandini, G;Vigneri, R
通讯作者：
Vigneri, R
影响因子：
3.8
作者：
Catalano, Stefania;Giordano, Cinzia;Barone, Ines
通讯作者：
Barone, Ines
影响因子：
5.7
作者：
Buck, Elizabeth;Gokhale, Prafulla C.;Miglarese, Mark R.
通讯作者：
Miglarese, Mark R.