Reflux drying of aerosols.
Reflux drying of aerosols.
复制标题
气溶胶的回流干燥。
DOI：
10.1089/jam.2004.17.344
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Hitzman,CoryJames
中科院分区：
文献类型：
--
作者：
Wiedmann,TimothyScott;Hitzman,CoryJames
我们努力的目标是产生高的雾化药物浓度，使整个吸入剂量可以在相对较短的时间间隔，通常是一分钟或更少的动物，在这份报告中，我们已经研究了使用回流冷凝器加上外部热源作为干燥气溶胶颗粒的手段。具体的兴趣是检查影响干燥过程的参数，并确定实际的实验条件，将允许干燥的气溶胶颗粒。用超声波驱动器雾化氯化铯水溶液，随后将产生的云状物通过外部加热的柱，该柱具有用流动水冷却的内部冷凝器。增加气流速度增加总质量（水+氯化铯）的输出，但降低颗粒的传输效率。在恒定的气流速度，降低壁面与冷凝器的温度比导致颗粒损失的逐步增加，但在水的去除效率观察到一个最大值。虽然热扩散和热泳效应可能会对干燥过程产生影响，但非稳态条件、对流、惯性冲击、湍流和冷凝器边界层的变化可能会对颗粒干燥产生影响。尽管有许多复杂性，但确定了具有高干燥质量传输效率的有效颗粒干燥的实际操作条件。
The goal of our efforts has been to generate high aerosolized drug concentrations, so that the entire inhaled dose may be delivered to the animal in a relatively short time interval, typically one minute or less. In this report, we have examined the use of a reflux condenser coupled with an external heat source as a means to dry aerosol particles. The specific interest was to examine the parameters influencing the drying process and identify practical experimental conditions that would allow drying of aerosol particles. Aqueous solutions of cesium chloride were atomized with an ultrasonic driver, and the resulting cloud was subsequently passed through an externally heated column with an inner condenser cooled with flowing water. Increasing the airflow rate increased the output of total mass(water + CsCl) but decreased the particle transit efficiency. At a constant airflow rate, decreasing the wall-to-condenser temperature ratio led to a progressive increase in particle loss, but a maximum was observed in the water removal efficiency. While thermal diffusion and the thermophoretic effect may have an impact on the drying process, non-steady state conditions, convective currents, inertial impaction, turbulence, and changes in the condenser boundary layer are likely to have a role in particle drying. In spite of the numerous complexities, practical operating conditions were identified for efficient particle drying with high dry mass transit efficiency.