Inhibitory effect of green tea on the growth of established skin papillomas in mice.
Inhibitory effect of green tea on the growth of established skin papillomas in mice.
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发表时间：
1992-12
期刊：
影响因子：
11.2
通讯作者：
Z. Y. Wang;M. Huang;C. Ho;R. Chang;W. Ma;T. Ferraro;K. Reuhl;C. S. Yang;A. Conney
中科院分区：
文献类型：
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作者：
Z. Y. Wang;M. Huang;C. Ho;R. Chang;W. Ma;T. Ferraro;K. Reuhl;C. S. Yang;A. Conney
在10个独立的实验中，用饮用水中的绿色茶或腹膜内注射绿色茶多酚级分或（-）-表没食子儿茶素没食子酸酯每周三次连续治疗具有已建立的化学诱导或UV光诱导的皮肤乳头状瘤的小鼠4-10周。在5个实验中观察到部分肿瘤消退或> 90%的肿瘤生长抑制，如通过每只小鼠的肿瘤体积变化所测量的，并且在另外5个实验中观察到肿瘤生长的显著抑制（46-89%）。用绿色茶或绿色茶成分治疗小鼠在几项但不是所有研究中对体重增加具有抑制作用。对所有10个实验数据的检查显示，在用饮用水中的绿色茶或腹膜内注射绿色茶成分治疗的346只携带乳头状瘤的小鼠中有14只（4%）发生完全肿瘤消退，而仅用载体治疗的220只携带乳头状瘤的对照小鼠中没有一只表现出完全肿瘤消退。这些观察结果表明，口服施用绿色茶、腹膜内施用绿色茶多酚级分或腹膜内施用（-）-表没食子儿茶素没食子酸酯抑制了已建立的实验诱导的皮肤乳头状瘤的生长和/或引起其消退。
In 10 separate experiments, mice with established chemically induced or UV light-induced skin papillomas were treated continuously with green tea in the drinking water or with i.p. injections of a green tea polyphenol fraction or (-)-epigallocatechin gallate three times a week for 4-10 weeks. Partial tumor regression or > 90% inhibition of tumor growth, as measured by changes in tumor volume per mouse, was observed in 5 experiments, and marked inhibition of tumor growth (46-89%) was observed in 5 additional experiments. Treatment of the mice with green tea or green tea constituents had an inhibitory effect on body weight increases in several but not all of the studies. Examination of the data from all ten experiments revealed that complete tumor regression occurred in 14 of 346 papilloma-bearing mice (4%) that were treated with green tea in the drinking water or with i.p. injections of green tea constituents, whereas none of the 220 papilloma-bearing control mice treated with only vehicle exhibited complete tumor regression. These observations indicate that oral administration of green tea, i.p. administration of a green tea polyphenol fraction, or i.p. administration of (-)-epigallocatechin gallate inhibited the growth and/or caused the regression of established experimentally induced skin papillomas.