Overweight and Obesity Associated With Increased Total Serum Calcium Level: Comparison of Cross-sectional Data in the Health Screening for Teaching Faculty
Overweight and Obesity Associated With Increased Total Serum Calcium Level: Comparison of Cross-sectional Data in the Health Screening for Teaching Faculty
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DOI：
10.1007/s12011-013-9856-8
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发表时间：
2013-11
影响因子：
3.9
通讯作者：
Xiaohua Ren;Ying-shui Yao;Lianping He;Yuelong Jin;Wei-Wei Chang-Wei;J. Li;Yan Chen;Xiu-li Song;Hui Tang;L. Ding;D. Guo;Chao-ping Li
中科院分区：
文献类型：
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作者：
Xiaohua Ren;Ying-shui Yao;Lianping He;Yuelong Jin;Wei-Wei Chang-Wei;J. Li;Yan Chen;Xiu-li Song;Hui Tang;L. Ding;D. Guo;Chao-ping Li
肥胖是心血管疾病的危险因素。我们以前的研究表明，血清钙水平可能对老年男性受试者的血压有影响。本研究的目的是评估血清总钙水平与超重和肥胖的关系。在我们的研究中，2006年招募了2,503名22-94岁的受试者进行常规健康筛查，测量了他们的超重和肥胖状况以及血清总钙水平。年龄的估计均值（p< 0.001），白色血细胞计数（p= 0.037），血红蛋白浓度（p< 0.001），红细胞计数（p< 0.001），血清总钙水平（p< 0.001），总胆固醇重量（p< 0.001），高密度脂蛋白胆固醇超重组和肥胖组的血清总胆固醇（p <0.001）、低密度脂蛋白胆固醇（p< 0.001）和甘油三酯（p< 0.001）显著高于非超重组。根据对数转换的总血清钙水平四分位数，受试者的超重/肥胖患病率为16.3- 30.5%。根据总血清钙水平四分位数，超重/肥胖受试者的患病率显示出显著的趋势（p< 0.001）。校正性别和年龄后，第二、第三和第四分位数与最低四分位数相比，超重/肥胖的比值比（OR）和95%置信区间（CI）分别为1.407（1.050-1.883）、1.543（1.136-2.095）和1.360（0.995-1.859）（p< 0.001）。这些结果表明，在中国人群中，成人超重/肥胖的患病率较高，与较高的血清总钙水平弱相关。
Obesity is a risk of cardiovascular diseases. Our previous studies revealed that serum calcium level may have influence in the blood pressure to older male subjects. The aim of this study was to evaluate the relationship between total serum calcium level and overweight and obesity subjects. In our study, overweight and obesity status and total serum calcium level were measured among 2,503 subjects, at age range of 22–94 years, who were recruited for the routine health screening in 2006. The estimated mean for age (p< 0.001), white blood cell count (p= 0.037), hemoglobin concentration (p< 0.001), red blood cell count (p< 0.001), total serum calcium level (p< 0.001), total cholesterol weight (p< 0.001), HDL-cholesterol (p< 0.001), LDL-cholesterol (p< 0.001), and triglyceride (p< 0.001) of overweight and obesity subjects were significantly higher than those of non-overweight subjects. The prevalence of overweight/obesity in subjects according to the log-transformed total serum calcium level quartiles was 16.3–30.5 %. The prevalence of overweight/obesity subjects showed trends that were significant according to the total serum calcium level quartiles (p< 0.001). The odds ratios (ORs) and 95 % confidence intervals (CIs) for overweight/obesity of the second, third, and fourth quartiles compared to the lowest quartile were 1.407 (1.050–1.883), 1.543 (1.136–2.095), and 1.360 (0.995–1.859), respectively, after adjusting for sex and age (p< 0.001). These findings suggest that a higher prevalence of adult overweight/obesity is weakly associated with higher total serum calcium level in the Chinese population.