The effects of alcohol on weight gain and the hypothalamic-pituitary-gonadotrophin axis in the maturing male rat.
The effects of alcohol on weight gain and the hypothalamic-pituitary-gonadotrophin axis in the maturing male rat.
复制标题
酒精对成熟雄性大鼠体重增加和下丘脑-垂体-促性腺激素轴的影响。
DOI：
10.1016/0006-2952(75)90426-8
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发表时间：
1975
影响因子：
5.8
通讯作者：
V. Marks
中科院分区：
文献类型：
--
作者：
A. Symons;V. Marks
从3周龄到10周龄，允许自由进食和15%（v/v）酒精代替自由饮水的雄性大鼠的生长速度略低于对照动物。这是由于较低的热量摄入。正常的基础黄体生成素（LH）水平的增加，发生在成熟的雄性大鼠完全废除酒精喂养。这不仅仅是（或仅仅）由于体重增加受损，（0.28 g）灌胃给150 g雄性大鼠，证实酒精能够在1小时内降低循环LH水平。垂体前叶对100 ng外源性促黄体生成素释放激素（LH-RH）的敏感性在酒精喂养和对照大鼠中相同，这表明酒精对生殖内分泌系统的影响是在下丘脑或更高的神经中枢。
Male rats allowed foodad lib.and 15% (v/v) alcohol in place of waterad lib.from 3 to 10 weeks of age were found to have a slightly slower growth rate than control animals. This was due to a lower caloric intake. The normal increase in basal luteinizing hormone (LH) levels that takes place during maturation in the male rat was completely abolished by alcohol feeding. That this was not only (or merely) due to impaired weight gain was suggested by the observation that intubation of alcohol (0.28 g) into 150-g male rats established that alcohol was capable of lowering circulating LH levels within 1 hr. The sensitivity of the anterior pituitary to 100 ng exogenous luteinizing hormone-releasing hormone (LH-RH) was the same in alcohol-fed and control rats, suggesting that the alcohol effect on the reproductive endocrine system is at the hypothalamic or higher neural centres.