Invasive aspergillosis in children and adolescents.
Invasive aspergillosis in children and adolescents.
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DOI：
10.2174/13816128113199990311
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发表时间：
2013-05
影响因子：
3.1
通讯作者：
A. Groll;D. Schrey;A. Tragiannidis;K. Bochennek;T. Lehrnbecher
中科院分区：
文献类型：
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作者：
A. Groll;D. Schrey;A. Tragiannidis;K. Bochennek;T. Lehrnbecher
侵袭性曲霉病是免疫功能低下儿童发病和死亡的重要原因。疾病控制取决于预防、早期诊断、预测性微生物信息、及时和适当的治疗以及宿主防御的恢复。与成人相比，儿童和青少年的侵袭性曲霉病在临床表现、流行病学，特别是新型诊断工具的使用和活性抗真菌药物的药代动力学方面具有独特性。在这里，我们回顾了儿童和青少年侵袭性曲霉病的表现和流行病学，并讨论了当前诊断工具以及这一特殊人群的治疗和预防策略和选择的价值。
Invasive aspergillosis is an important cause of morbidity and mortality in immunocompromised children. Disease control depends on prevention, early diagnosis, predictive microbiological information, prompt and appropriate treatment and restoration of host defenses. Relative to adults, invasive aspergillosis in children and adolescents is unique in its clinical presentation, epidemiology, and in particular, the utility of newer diagnostic tools and the pharmacokinetics of active antifungal agents. Here we review the presentation and epidemiology of invasive aspergillosis in children and adolescents and discuss the value of current diagnostic tools and strategies and options for treatment and prevention in this special population.