Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus.
Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus.
复制标题
淋巴细胞性脉络膜脑膜炎病毒感染培养的小鼠腹腔巨噬细胞。
DOI：
--
复制
发表时间：
1978
影响因子：
3.8
通讯作者：
F. Lehmann
中科院分区：
文献类型：
--
作者：
R. Schwartz;J. Löhler;F. Lehmann
淋巴细胞脉络丛脑膜炎病毒株 WE 在未刺激 NMRI 小鼠的培养腹膜巨噬细胞中繁殖。免疫荧光技术显示，大多数细胞参与了感染过程。然而，它们的功能并未改变。从形态上看，受感染的细胞含有更多的细胞质空泡，但这些空泡也存在于未感染的衰老细胞和具有吞噬乳胶珠的细胞中，尽管数量较少。与WE株病毒相比，E-350（阿姆斯特朗）株繁殖较慢，滴度较低，但感染细胞的比例相似。
Lymphocytic choriomeningitis virus strain WE multiplied in cultivated peritoneal macrophages from unstimulated NMRI mice. As revealed by immunofluorescence technique, most cells participated in the infectious process. They were not, however, functionally altered. Morphologically, infected cells contained more cytoplasmic vacuoles, but these were also present, though less numerous, in uninfected ageing cells and in cells having phagocytosed Latex beads. As compared with the WE strain virus, the E-350 (Armstrong) strain multiplied more slowly to lower titres, but the proportion of infected cells was similar.