Ru-Catalyzed One-Pot Diannulation of Heteroaryls: Direct Access to π-Conjugated Polycyclic Amides.
Ru-Catalyzed One-Pot Diannulation of Heteroaryls: Direct Access to π-Conjugated Polycyclic Amides.
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DOI：
10.1021/acs.orglett.6b03314
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发表时间：
2016-12
期刊：
影响因子：
5.2
通讯作者：
Majji Shankar;Koushik Ghosh;Kallol Mukherjee;Raja K. Rit;A. Sahoo
中科院分区：
文献类型：
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作者：
Majji Shankar;Koushik Ghosh;Kallol Mukherjee;Raja K. Rit;A. Sahoo
报道了一种新型的Ru催化的对称和不对称的杂芳烃氧化双环反应。首次提出了两种不同结构的杂芳烃不对称环化反应的一般方法。甲基苯基亚磺胺(MPS)在杂芳烃的环化中起着重要的作用，可以通过一次操作形成多个C-C和C-N键，从而构建结构复杂的π共轭杂芳烃稠合多环酰胺骨架。该反应具有良好的底物范围和对多种官能团的耐受性。
A novel Ru-catalyzed oxidative double annulation of heteroarenes with symmetrical and unsymmetrical alkynes is reported. A general method for the unsymmetrical annulation of heteroarenes with two distinct alkynes is showcased for the first time. Methylphenyl sulfoximine (MPS) plays an important role in the annulations of heteroarenes and allows the construction of structurally complex π-conjugated heteroarene-fused polycyclic amide skeletons via the formation of multiple C-C and C-N bonds in a single operation. The reaction exhibits excellent substrate scope and tolerates a wide range of functional groups.