Diacetylenic Lipid Tubules: Experimental Evidence for a Chiral Molecular Architecture
Diacetylenic Lipid Tubules: Experimental Evidence for a Chiral Molecular Architecture
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DOI：
10.1126/science.264.5161.945
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发表时间：
1994-05
期刊：
影响因子：
56.9
通讯作者：
J. Schnur;B. Ratna;Jonathan V Selinger;A. Singh;G. Jyothi;K. Easwaran
中科院分区：
文献类型：
--
作者：
J. Schnur;B. Ratna;Jonathan V Selinger;A. Singh;G. Jyothi;K. Easwaran
分子自组装是先进材料合理设计的关键。为了研究分子结构和随后的自组装微结构之间的因果关系，研究了双乙酰类脂的自组装小管。圆二色谱研究给出了实验证据，证明微管的形成是由手性分子堆积驱动的，这与最近的微管理论相一致。在此基础上，提出了小管形成的分子机制。
Molecular self-assembly is of key importance for the rational design of advanced materials. To investigate the causal relation between molecular structure and the consequent self-assembled microstructure, self-assembled tubules of diacetylenic lipids were studied. Circular-dichroism studies give experimental evidence that the formation of tubules is driven by chiral molecular packing, in agreement with recent theories of tubules. On the basis of these results, a molecular mechanism for the formation of tubules is proposed.