ACTIN CABLES AND EPIDERMAL MOVEMENT IN EMBRYONIC WOUND-HEALING
ACTIN CABLES AND EPIDERMAL MOVEMENT IN EMBRYONIC WOUND-HEALING
复制标题
DOI：
10.1038/360179a0
复制
发表时间：
1992-11-12
期刊：
影响因子：
64.8
通讯作者：
LEWIS, J
中科院分区：
文献类型：
--
作者：
MARTIN, P;LEWIS, J
胚胎中的皮肤伤口愈合迅速而完美。即使表皮在一个结构的表面上看起来是拉紧的，比如一个正在生长的肢芽，它对创伤的反应是在损伤处闭合，而不是更广泛地张开。在成人伤口中，表皮似乎通过片状伪足迁移，在暴露的结缔组织上爬行1 -5。但在胚胎的伤口中我们看不到板状伪足。伤口边缘的表皮看起来很光滑，好像受到了圆周张力。在这里，我们表明，电缆的丝状肌动蛋白似乎连续运行周围的伤口边缘。 局限于表皮游离缘的单排基底细胞。我们认为，肌动蛋白电缆作为一个收缩的“荷包”关闭胚胎伤口。
SKIN wounds in embryos heal rapidly and perfectly. Even though the epidermis appears to be stretched taut over the surface of a structure such as a growing limb bud, its response to wounding is to close over the lesion, rather than to gape more widely. In adult wounds, the epidermis seems to migrate by means of lamellipodia, crawling over the exposed connective tissue1-5. But in embryonic wounds we do not see lamellipodia. The epidermis at the edge of the wound looks smooth, as though under a circumferential tension. Here we show that a cable of filamentous actin appears to run continuously around most of the wound margin. It is confined to the single row of basal cells at the free edge of the epidermis. We suggest that the actin cable acts as a contractile 'purse string' to close up the embryonic wound.