Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma
Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma
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DOI：
10.1002/path.1827
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发表时间：
2005-10-01
影响因子：
7.3
通讯作者：
Yasui, W
中科院分区：
文献类型：
--
作者：
Oue, N;Mitani, Y;Yasui, W
再生胰岛衍生家族成员4(REG IV)是癌症和炎症性肠病的候选标记物。本研究采用免疫组织化学方法检测了289例人多种肿瘤组织和非肿瘤组织中Reg IV的表达。胃小凹上皮不表达REG IV，肠化生的杯状细胞和肠化生底部的神经内分泌细胞表达REG IV。小肠和结肠的神经内分泌细胞表达REG IV，而小肠和结肠的杯状细胞表达弱或不表达REG IV。内分泌胰岛β细胞表达REG IV。未发现Reg IV的表达与肿瘤分期和患者预后等临床特征之间的相关性。36例结直肠腺癌中，13例(36.1%)表达REG IV，阳性表达与肿瘤分期有关(P=0.0379，Fisher‘s精确检验)。15例结直肠类癌中有14例(93.3%)表达Reg IV。23例胰腺导管腺癌中5例(21.7%)表达REG IV。相比之下，肺癌(n=30)和乳腺癌(n=30)不表达Reg IV。这是首次对Reg IV蛋白在人类肿瘤中的表达和分布进行的免疫组织化学分析。这些数据表明，Reg IV在胃肠道和胰腺肿瘤中表达，包括腺癌和类癌，并且Reg IV与胃和胃癌的肠道和神经内分泌分化有关。版权所有(C)2005年大不列颠和爱尔兰病理学会。作者：John Wiley&Sons，Ltd.
Regenerating islet-derived family, member 4 (Reg IV) is a candidate marker for cancer and inflammatory bowel disease. In the present study, immunohistochemical analysis of Reg IV was performed in various human neoplastic (n = 289) and non-neoplastic tissues. In the stomach, foveolar epithelium was negative for Reg IV, whereas goblet cells of intestinal metaplasia and neuroendocrine cells at the base of intestinal metaplasia expressed Reg IV. Neuroendocrine cells of the small intestine and colon showed strong expression of Reg IV, whereas goblet cells of the small intestine and colon showed weak or no expression of Reg IV. Insulin-producing beta cells of the endocrine pancreas were positive for Reg IV. Among 143 gastric adenocarcinomas, Reg IV expression was detected in 42 (29.4%) and was associated with both the intestinal mucin phenotype and neuroendocrine differentiation. No association was found between Reg IV expression and clinical characteristics such as tumour stage and patient prognosis. Of 36 colorectal adenocarcinomas, 13 (36.1%) were positive for Reg IV, which was associated with tumour stage (p = 0.0379, Fisher's exact test). Expression of Reg IV was detected in 14 (93.3%) of 15 colorectal carcinoid tumours. Reg IV expression was also detected in 5 (21.7%) of 23 ductal adenocarcinomas of the pancreas. In contrast, lung cancers (n = 30) and breast cancers (n = 30) did not express Reg IV. This is the first immunohistochemical analysis of the expression and distribution of Reg IV protein in human tumours. These data suggest that Reg IV is expressed by gastrointestinal and pancreatic tumours, including adenocarcinomas and carcinoid tumours, and that Reg IV is associated with intestinal and neuroendocrine differentiation of the stomach and gastric carcinoma. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.