Randomized Trial Comparing Conventional-Dose With High-Dose Conformal Radiation Therapy in Early-Stage Adenocarcinoma of the Prostate: Long-Term Results From Proton Radiation Oncology Group/American College of Radiology 95-09
Randomized Trial Comparing Conventional-Dose With High-Dose Conformal Radiation Therapy in Early-Stage Adenocarcinoma of the Prostate: Long-Term Results From Proton Radiation Oncology Group/American College of Radiology 95-09
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DOI：
10.1200/jco.2009.25.8475
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发表时间：
2010-03-01
影响因子：
45.3
通讯作者：
Rossi, Carl J.
中科院分区：
文献类型：
--
作者：
Zietman, Anthony L.;Bae, Kyounghwa;Rossi, Carl J.
研究对象与方法前列腺癌患者T1b-T2b，前列腺特异性抗原=3的患者有3次泌尿生殖系统毒性，高剂量组有1%的患者出现晚期胃肠道毒性。结论这项随机对照试验对接受高剂量放射治疗的局限性前列腺癌患者具有更好的长期癌症控制效果。这是在没有增加3级晚期尿路或直肠并发症的情况下实现的。J Clin Oncol28：1106-1111。(C)2010年美国临床肿瘤学会
PurposeTo test the hypothesis that increasing radiation dose delivered to men with early-stage prostate cancer improves clinical outcomes.Patients and MethodsMen with T1b-T2b prostate cancer and prostate-specific antigen = 3 genitourinary toxicity, and 1% of patients in the high-dose arm experienced late grade >= 3 GI toxicity.ConclusionThis randomized controlled trial shows superior long-term cancer control for men with localized prostate cancer receiving high-dose versus conventional-dose radiation. This was achieved without an increase in grade >= 3 late urinary or rectal morbidity. J Clin Oncol 28: 1106-1111. (C) 2010 by American Society of Clinical Oncology