ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.
ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.
复制标题
ASK1依赖性募集和巨噬细胞的激活会引起皮肤伤口的头发生长。
DOI：
10.1083/jcb.200611015
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发表时间：
2007-03-26
影响因子：
7.8
通讯作者：
Ichijo, Hidenori
中科院分区：
文献类型：
--
作者：
Osaka, Nao;Takahashi, Takumi;Murakami, Shiori;Matsuzawa, Atsushi;Noguchi, Takuya;Fujiwara, Takeshi;Aburatani, Hiroyuki;Moriyama, Keiji;Takeda, Kohsuke;Ichijo, Hidenori
凋亡信号调节激酶1（ASK 1）是丝裂原活化蛋白3-激酶家族的成员，其响应于炎性细胞因子和物理化学应激而激活c-Jun NH 2-末端激酶和p38途径。我们报告说，ASK 1缺乏小鼠的结果在皮肤创伤诱导的毛发再生显着迟缓。寡核苷酸微阵列分析显示，在ASK 1缺陷小鼠的皮肤伤口区域，几种巨噬细胞趋化和激活因子以及几种巨噬细胞特异性标记基因的表达减少。在野生型和ASK 1缺陷型小鼠中，皮内移植经精氨酸激活的骨髓源性巨噬细胞强烈诱导毛发生长。这些发现表明，ASK 1是创伤诱导的巨噬细胞浸润和活化所必需的，巨噬细胞在皮肤中炎症依赖性毛发再生中发挥核心作用。
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein 3-kinase family that activates both c-Jun NH2-terminal kinase and p38 pathways in response to inflammatory cytokines and physicochemical stress. We report that ASK1 deficiency in mice results in dramatic retardation of wounding-induced hair regrowth in skin. Oligonucleotide microarray analysis revealed that expression of several chemotactic and activating factors for macrophages, as well as several macrophage-specific marker genes, was reduced in the skin wound area of ASK1-deficient mice. Intracutaneous transplantation of cytokine-activated bone marrow-derived macrophages strongly induced hair growth in both wild-type and ASK1-deficient mice. These findings indicate that ASK1 is required for wounding-induced infiltration and activation of macrophages, which play central roles in inflammation-dependent hair regrowth in skin.