Peri-tumoral hyperintensity on hepatobiliary phase of gadoxetic acid-enhanced MRI in hepatocellular carcinomas: correlation with peri-tumoral hyperplasia and its pathological features
Peri-tumoral hyperintensity on hepatobiliary phase of gadoxetic acid-enhanced MRI in hepatocellular carcinomas: correlation with peri-tumoral hyperplasia and its pathological features
复制标题
肝细胞癌钆塞酸增强MRI肝胆相瘤周高信号与瘤周增生及其病理特征的相关性
DOI：
10.1007/s00261-017-1437-4
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发表时间：
2017
影响因子：
2.4
通讯作者：
Gabata Toshifumi
中科院分区：
文献类型：
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作者：
Yoneda Norihide;Matsui Osamu;Kitao Azusa;Komori Takahiro;Kozaka Kazuto;Ikeda Hiroko;Yoshida Kotaro;Inoue Dai;Minami Tetsuya;Koda Wataru;Kobayashi Satoshi;Gabata Toshifumi
肝细胞癌（HCC）在钆塞酸增强MRI（EOB-MRI）肝胆（HB）期偶见瘤周高信号（P-高信号）。最近的一项研究报告了肝癌或转移癌中与谷氨酰胺合成酶（GS）过表达相关的瘤周增生（P-增生）。本研究的目的是分析之间的相关性P-高信号的HB阶段和GS表达表明P-增生，并揭示其病理feature.Methods77手术切除HCC从68例患者进行了分析。根据肿瘤周围高信号的程度将HB期P信号分为0级（无P信号）、1级（肿瘤边缘小于50%）、2级（50%~ 80%）、3级（80%~ 100%）。进行GS和有机阴离子转运蛋白多肽（OATP）1B 3的免疫组织化学染色。P-hyperplasia（peri-tumoral GS expression）与OATP 1B 3表达、P-高信号和肿瘤病理特征之间的关系进行了分析。在3/34（8.8%）例P-高信号0级、16/29（55.2%）例1级、9/10（90%）例2级和4/4（100%）例3级中观察到P-增生。与0级相比，P-高信号1-3级中P-增生的发生率显著增加（p< 0.0001）。所有P-增生部位的肝细胞均显示明确的OATP 1B 3表达。P-高信号阳性HCC的肝静脉侵犯率显著高于阴性HCC（p= 0.0017）。结论HCC HB期P-高信号可能提示P-增生伴GS和OATP 1B 3表达，肝静脉侵犯率较高。
PurposePeri-tumoral hyperintensity (P-hyperintensity) is occasionally seen in hepatocellular carcinoma (HCC) on the hepatobiliary (HB) phase of gadoxetic acid-enhanced MRI (EOB-MRI). A recent study reported peri-tumoral hyperplasia (P-hyperplasia) associated with over-expression of glutamine synthetase (GS) in HCC or metastatic carcinoma. The aim of this study was to analyze the correlation between P-hyperintensity on the HB phase and GS expression indicating P-hyperplasia and reveal its pathological features.MethodsSeventy-seven surgically resected HCCs from 68 patients were analyzed. The grade of P-hyperintensity on HB phase was divided according to the degree of the peri-tumoral hyperintense signal: grade 0 (no P-hyperintensity), grade 1 (less than 50% of the tumor border), grade 2 (50%–80%), grade 3 (80%–100%). Immunohistochemical staining for GS and organic anion transporter polypeptides (OATP)1B3 was performed. The relationships among P-hyperplasia (peri-tumoral GS expression) and OATP1B3 expression, P-hyperintensity, and pathological features of the tumor were analyzed.ResultsThirty-four HCCs were classified as P-hyperintensity grade 0, 29 HCCs as grade 1,10 nodules as grade 2, and 4 HCCs as grade 3. P-hyperplasia was observed in 3/34 (8.8%) P-hyperintensity grade 0, 16/29 (55.2%) grade 1, 9/10 (90%) grade 2, and 4/4 (100%) grade 3. The incidence of P-hyperplasia was significantly increased in P-hyperintensity grades 1–3 compared with grade 0 (p< 0.0001). Hepatocytes in all P-hyperplasia sites demonstrated definite OATP1B3 expression. Microscopic hepatic venous invasion was significantly increased in P-hyperintensity-positive HCCs compared with negative HCCs (p= 0.0017).ConclusionsP-hyperintensity on HB phase in HCC may indicate p-hyperplasia with GS and OATP1B3 expression and a higher incidence of microscopic hepatic venous invasion.