Increased interleukin-11 levels in thoracic aorta and plasma from patients with acute thoracic aortic dissection
Increased interleukin-11 levels in thoracic aorta and plasma from patients with acute thoracic aortic dissection
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急性胸主动脉夹层患者胸主动脉和血浆中白细胞介素 11 水平升高
DOI：
10.1016/j.cca.2018.03.014
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发表时间：
2018
影响因子：
5
通讯作者：
Wan Jun
中科院分区：
文献类型：
--
作者：
Xu Yao;Ye Jing;Wang Menglong;Wang Yuan;Ji Qingwei;Huang Ying;Zeng Tao;Wang Zhen;Ye Di;Jiang Huimin;Liu Jianfang;Lin Yingzhong;Wan Jun
白介素11(IL-11)与肿瘤和血液系统疾病密切相关。最近的研究表明，IL-11还参与了心血管疾病，包括缺血再灌注介导的心脏损伤和急性心肌梗死。本研究旨在探讨IL-11在急性胸主动脉夹层(TAD)发病中的作用。方法收集正常人和急性TAD患者的主动脉组织标本，分析IL-11在所有组织中的表达。此外，采集胸痛患者的血样，根据胸主动脉CT血管成像结果分为非AD组(NAD组)和TAD组。结果急性TAD患者主动脉组织中IL-11、IL-17和干扰素γ水平较正常对照组明显升高，尤以撕裂段升高最为明显。IL-11来源于TAD大鼠的主动脉巨噬细胞。此外，急性TAD患者血浆IL-11、IL-17和干扰素-γ水平显著高于非AD患者，相关分析显示IL-11水平与IL-γ、IL-17、血糖、收缩压、舒张压、白细胞、C反应蛋白和D-二聚体水平呈正相关。二元Logistic回归分析显示，对TAD有诊断价值的患者中IL-11水平升高，但D-二聚体水平较低。结论TAD患者胸主动脉和血浆中IL-11水平升高，可作为TAD诊断的一项有价值的生物标志物。
BackgroundInterleukin (IL) 11 is closely related to tumor and hematological system diseases. Recent studies have demonstrated that IL-11 also participates in cardiovascular diseases, including ischemia-reperfusion mediated heart injury and acute myocardial infarction. This study aimed to investigate whether IL-11 is involved in acute thoracic aortic dissection (TAD).MethodsAortic tissue samples from normal donors and acute TAD patients were collected, and the expression of IL-11 in all aortic tissue was analyzed. In addition, blood samples from patients with chest pain were collected and divided into a non-AD (NAD) group and a TAD group according to the results of computed tomography angiography of the thoracic aorta. The plasma IL-11, IL-17 and interferon (IFN) γ in all blood samples were measured.ResultsCompared with aortic tissue of normal controls, IL-11 was significantly increased in aortic tissue of acute TAD patients, especially in the torn section. The IL-11 was derived from aorta macrophages in TAD. In addition, the plasma IL-11, IL-17 and IFN-γ were significantly higher in acute TAD patients than in NAD patients, and the correlation analysis showed that IL-11 levels were positively correlated with levels of IFN-γ, IL-17, glucose, systolic blood pressure, diastolic blood pressure, white blood cells, C-reactive proteins and D-dimers. Binary logistic regression analyses showed that elevated IL11 in patients who may have diagnostic value of TAD, but less that D-dimer.ConclusionIL-11 was increased in thoracic aorta and plasma of TAD patients and may be a promising biomarker for diagnosis in patients with TAD.