Cortical and structural-connectivity damage correlated with impaired syntactic processing in aphasia
Cortical and structural-connectivity damage correlated with impaired syntactic processing in aphasia
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DOI：
10.1002/hbm.24514
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发表时间：
2019-05-01
影响因子：
4.8
通讯作者：
Fridriksson, Julius
中科院分区：
文献类型：
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作者：
den Ouden, Dirk-Bart;Malyutina, Svetlana;Fridriksson, Julius
失语症中的语法缺失不是一种同质的综合征，而是一组不统一的语言行为的特征，其中语法标记和复杂的句法结构被省略、简化或误解。在一个样本的71个左半球中风幸存者，句法处理量化与西北评估动词和句子（NAVS）。分类分析被用来评估之间的关系NAVS性能和morphosyntactically减少语音图片描述。采用基于体素和基于连接性的损伤-症状映射研究句法加工障碍的神经相关因素。尽管NAVS性能和形态句法生产赤字之间的非随机对应关系，有个别模式的句法处理的变化。左半球下额叶皮质的损伤预测了形态结构上的产量减少。受损的动词论点结构生产预测左半球后上级颞回和角回，以及颞叶和额叶皮质之间的腹侧通路的损害。这一通路的损伤也预示着句子理解和产生受损，特别是非规范句子。虽然agrammatic语音生产主要是预测下额叶皮层的病变，句法处理的其他方面，而依赖于区域完整性颞顶皮层和腹侧流。
Agrammatism in aphasia is not a homogeneous syndrome, but a characterization of a nonuniform set of language behaviors in which grammatical markers and complex syntactic structures are omitted, simplified, or misinterpreted. In a sample of 71 left-hemisphere stroke survivors, syntactic processing was quantified with the Northwestern Assessment of Verbs and Sentences (NAVS). Classification analyses were used to assess the relation between NAVS performance and morphosyntactically reduced speech in picture descriptions. Voxel-based and connectivity-based lesion-symptom mapping were applied to investigate neural correlates of impaired syntactic processing. Despite a nonrandom correspondence between NAVS performance and morphosyntactic production deficits, there was variation in individual patterns of syntactic processing. Morphosyntactically reduced production was predicted by lesions to left-hemisphere inferior frontal cortex. Impaired verb argument structure production was predicted by damage to left-hemisphere posterior superior temporal and angular gyrus, as well as to a ventral pathway between temporal and frontal cortex. Damage to this pathway was also predictive of impaired sentence comprehension and production, particularly of noncanonical sentences. Although agrammatic speech production is primarily predicted by lesions to inferior frontal cortex, other aspects of syntactic processing rely rather on regional integrity in temporoparietal cortex and the ventral stream.