Anti-microbial photodynamic therapy: useful in the future?
Anti-microbial photodynamic therapy: useful in the future?
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DOI：
10.1007/s10103-006-0409-7
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发表时间：
2007-06-01
影响因子：
2.1
通讯作者：
Maisch, Tim
中科院分区：
文献类型：
--
作者：
Maisch, Tim
本卷的前几章集中于PDT的基本原理和临床应用。本章将试图概述新兴的研究领域，以确定一些新的应用程序，可能成为有用的，在未来的临床实践。抗生素耐药性在全球范围内的上升推动了新的抗微生物策略的研究。由MRSA引起的皮肤疾病理想地适合于通过抗微生物光动力疗法进行治疗，用于根除局部感染和用于调节伤口愈合，这是由于局部施用能够递送光敏剂和光。使用光敏剂和光作为抗微生物剂对抗牙周微生物生物膜也应该代表消除口腔细菌的有吸引力的方法。适当的光源，激光和非相干光将简要覆盖。本章将集中在一些方面的抗微生物光动力疗法，似乎是有前途的皮肤适应症和口腔内的致病菌灭活。
Previous chapters in this volume have focused on fundamental principles and clinical applications of PDT. This chapter will attempt to outline emerging areas of research to identify some new applications that may become useful in the future in clinical practise. The worldwide rise in antibiotic resistance has driven research to the development of novel anti-microbial strategies. Cutaneous diseases caused by MRSA are ideally suited to treatment by anti-microbial photodynamic therapy for eradicating localized infections and for modulating wound healing due to the ability to deliver photosensitizer and light with topical application. The use of photosensitizer and light as an anti-microbial agent against periodontal microbial biofilms should also represent an attractive method of eliminating oral bacteria. Suitable light sources, laser light and non-coherent light will be briefly covered. This chapter will focus on some aspects of anti-microbial photodynamic therapy that appear to be promising for dermatological indications and inactivation of pathogenic bacteria within the oral cavity.