Quantitative tissue sodium concentration mapping of normal rat brain
Quantitative tissue sodium concentration mapping of normal rat brain
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DOI：
10.1002/mrm.1910360115
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发表时间：
1996-07-01
影响因子：
3.3
通讯作者：
Thulborn, KR
中科院分区：
文献类型：
--
作者：
Christensen, JD;Barrere, BJ;Thulborn, KR
通过 MRI 获得组织钠浓度 (TSC) 图的定量体内方法与正常大鼠大脑中的侵入性全局 Na-22 放射性核素稀释技术进行比较，NIR 方法使用三维投影采集方案来最大限度地减少横向弛豫造成的信号损失，内部校准标准用于在校正 B-1 不均匀性后将信号强度转换为 TSC 使用在两个频率下具有相同 B-1 分布和灵敏度获得的 Na-23 和 H-1 图像的比率，在生物浓度范围内，以 Na-23 和 H-1 的 MR 信号比率测量的 TSC 给出与浓度的线性响应，在正常大鼠大脑中，使用 MRI 方法（TSC = 45 +/- 4 mM，动物 = 5）测量的平均 TSC 与整体 Na-22 没有显着差异 放射性核素方法（TSC = 49 +/- 6 mM，动物 = 7）。
A quantitative in vivo method for obtaining maps of tissue sodium concentration (TSC) by MRI is compared to the invasive, global Na-22 radionuclide dilutional technique in the normal rat brain, The NIR method uses a three-dimensional projectional acquisition scheme to minimize signal losses from transverse relaxation, Internal calibration standards are used to convert the signal intensity into TSC after correction for B-1 inhomogeneities by using the ratio of Na-23 and H-1 images obtained with identical B-1 distributions and sensitivities at the two frequencies, Over the biological range of concentrations, the TSC, measured as the ratio of MR signals of Na-23 and H-1, gives a linear response with concentration, In the normal rat brain, the mean TSC measured using the MRI method (TSC = 45 +/- 4 mM, animals = 5) is not significantly different from the global Na-22 radionuclide method (TSC = 49 +/- 6 mM, animals = 7).