On the structural, mechanical, and biodegradation properties of HA/β-TCP robocast scaffolds
On the structural, mechanical, and biodegradation properties of HA/β-TCP robocast scaffolds
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DOI：
10.1002/jbm.b.32935
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发表时间：
2013-10-01
影响因子：
3.4
通讯作者：
Tomsia, Antoni P.
中科院分区：
文献类型：
--
作者：
Houmard, Manuel;Fu, Qiang;Tomsia, Antoni P.
羟基磷灰石/-磷酸三钙（HA/-TCP）复合支架材料在骨组织工程中具有广阔的应用前景。在这项工作中，陶瓷支架与不同的HA/-TCP组合物（纯HA，60 HA/40-TCP，和20 HA/80-TCP）制造的机器人辅助沉积（robocasting）技术，使用水基水凝胶墨水。对支架的孔隙率、力学性能和降解性能进行了系统的研究。我们的研究结果表明，在相似的体积孔隙率，烧结支架的机械强度增加与杆直径的减小。所制造的支架的压缩强度（孔隙率约为25-80体积%）在约3至约50 MPa之间变化，该值等于或高于人松质骨的压缩强度（2-12 MPa）。尽管5个月后水中的Ca和P离子略有增加，但没有观察到支架在SBF或水中的明显降解。我们从这项工作中的发现表明，复合磷酸钙支架与客户设计的化学和建筑可以通过机器人辅助沉积方法制造。(c)2013 Wiley Periodicals，Inc. J Biomed Mater Res Part B：Appl Biomater 101 B：1233-1242，2013.
Hydroxyapatite/-tricalcium phosphate (HA/-TCP) composite scaffolds have shown great potential for bone-tissue engineering applications. In this work, ceramic scaffold with different HA/-TCP compositions (pure HA, 60HA/40-TCP, and 20HA/80-TCP) were fabricated by a robotic-assisted deposition (robocasting) technique using water-based hydrogel inks. A systematic study was conducted to investigate the porosity, mechanical property, and degradation of the scaffolds. Our results indicate that, at a similar volume porosity, the mechanical strength of the sintered scaffolds increased with the decreasing rod diameter. The compressive strength of the fabricated scaffolds (porosity approximate to 25-80 vol %) varied between approximate to 3 and approximate to 50 MPa, a value equal or higher than that of human cancellous bone (2-12 MPa). Although there was a slight increase of Ca and P ions in water after 5 month, no noticeable degradation of the scaffolds in SBF or water was observed. Our findings from this work indicate that composite calcium phosphate scaffolds with customer-designed chemistry and architecture may be fabricated by a robotic-assisted deposition method. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1233-1242, 2013.