Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: response pathways initiated in nearby viable cells.
Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: response pathways initiated in nearby viable cells.
复制标题
凋亡和坏死细胞作为局部组织应激和炎症的哨兵：在附近活细胞中启动的反应途径。
DOI：
10.1080/08916930902832124
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发表时间：
2009
期刊：
影响因子：
3.5
通讯作者：
Levine,JerroldS
中科院分区：
文献类型：
--
作者：
Patel,VimalA;Lee,DanielJ;Longacre-Antoni,Angelika;Feng,Lanfei;Lieberthal,Wilfred;Rauch,Joyce;Ucker,DavidS;Levine,JerroldS
事实上，身体中的所有细胞都有能力识别死亡细胞并对其做出反应。活细胞通过不同的细胞表面受体区分apo和nec。这些受体的参与诱导了在活性应答细胞中的“免疫依赖性”信号传导事件，其对于apo与nec靶点不同。虽然“吞噬依赖性”信号事件也有助于活细胞的反应，但这些事件对于apo和nec靶点没有区别。虽然许多信号事件在不同的细胞谱系中是保守的，但其他信号事件，特别是涉及Akt的信号事件，表现出谱系特异性变异。而apo靶点激活MΦ中的Akt，它们抑制肾上皮细胞中的Akt。存活的迁移细胞（如MΦ）和存活的固定细胞（如肾上皮细胞）对死亡靶标的反应差异允许细胞特异性适应局部环境变化或应激。我们认为死细胞（apo和nec）可以作为哨兵，提醒附近的活细胞注意局部环境变化或压力。
Virtually all cells in the body have the capacity to recognize and respond to dead cells. Viable cells discriminate apo from nec targets via distinct cell surface receptors. Engagement of these receptors induces “recognition-dependent” signaling events in viable responding cells that differ for apo vs. nec targets. Although “engulfment-dependent” signaling events also contribute to the response by viable cells, these events do not differ for apo vs. nec targets. While many signaling events are conserved across diverse cell lineages, other signaling events, especially those involving Akt, demonstrate lineage-specific variation. Whereas apo targets activate Akt in MΦ, they inhibit Akt in kidney epithelial cells. Differences in the responses to dead targets by viable migratory cells, such as MΦ, and viable fixed cells, such as kidney epithelial cells, permit cell-specific adaptations to local environmental change or stress. We propose that dead cells (apo and nec) act as sentinels to alert nearby viable cells to local environmental change or stress.