HER2 testing in a population-based study of patients with metastatic breast cancer treated with trastuzumab.
HER2 testing in a population-based study of patients with metastatic breast cancer treated with trastuzumab.
复制标题
对接受曲妥珠单抗治疗的转移性乳腺癌患者进行的一项基于人群的研究中的 HER2 检测。
DOI：
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发表时间：
2008
影响因子：
4.6
通讯作者：
T. Whelan
中科院分区：
文献类型：
--
作者：
F. O'Malley;T. Thomson;J. Julian;Cherry L. Have;R. Cosby;K. Gelmon;I. Andrulis;T. Whelan
CONTEXT
The development of trastuzumab has led to new therapeutic strategies for patients with breast cancer. Trastuzumab has been shown to only be effective in those patients whose cancers are HER2 positive by either immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH).
OBJECTIVE
To determine the accuracy of HER2 testing in 2 provinces in Canada.
DESIGN
Patients with metastatic breast cancer diagnosed between 1999 and 2002 who were HER2 positive in the local laboratories were included in this study. All cases were retested centrally, by IHC (using 4 methods) and FISH. In addition, 205 locally reported HER2-negative metastatic breast cancer cases were retested centrally.
RESULTS
Concordance between the 505 local IHC-positive cases with central IHC testing varied between 79.3% and 89.6% depending on the IHC method and scoring method used. HER2 gene amplification by FISH was present in 86.1% of local IHC-positive cases. Concordance between the 205 local IHC-negative tumors with central testing ranged between 94.8% and 100% for IHC and was 98.5% for FISH.
CONCLUSIONS
This study demonstrated that locally reported HER2-negative results were highly accurate, but less accuracy was demonstrated with local HER2-positive results. These results emphasize the need for participation in a quality assurance program.
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影响因子：
10.3
作者：
Paik, S;Bryant, J;Wolmark, N
通讯作者：
Wolmark, N
影响因子：
158.5
作者：
Romond, EH;Perez, EA;Wolmark, N
通讯作者：
Wolmark, N
影响因子：
10.3
作者：
Roche, PC;Suman, VJ;Perez, EA
通讯作者：
Perez, EA
影响因子：
56.9
作者：
SLAMON, DJ;GODOLPHIN, W;PRESS, MF
通讯作者：
PRESS, MF