CD98 signals controlling tumorigenesis
CD98 signals controlling tumorigenesis
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DOI：
10.1016/j.biocel.2016.11.005
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发表时间：
2016-12-01
影响因子：
4
通讯作者：
Sethi, Tariq
中科院分区：
文献类型：
--
作者：
Ip, Hugh;Sethi, Tariq
CD98 与多种癌症有关。 CD98 调节氨基酸转运和整合素信号传导，这是肿瘤进展的关键驱动因素。 CD98 异二聚体中的轻链起到氨基酸交换器的作用。重链与轻链一起在质膜上形成异质复合物以介导信号传导途径。在本文中，我们回顾了阻断 CD98 活性的各种方法，这可能会为癌症治疗带来新的机会。 (C) 2016 Elsevier Ltd. 保留所有权利。
CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways. In this article, we review various approaches to blocking CD98 activity, which may lead to novel opportunities in cancer therapeutics. (C) 2016 Elsevier Ltd. All rights reserved.