Inhibition of DNA replication in camptothecin-treated cells is regulated by protein kinases.
Inhibition of DNA replication in camptothecin-treated cells is regulated by protein kinases.
复制标题
喜树碱处理的细胞中 DNA 复制的抑制是由蛋白激酶调节的。
DOI：
10.1111/j.1749-6632.2000.tb07064.x
复制
发表时间：
2000
影响因子：
5.2
通讯作者：
Wang,Y
中科院分区：
文献类型：
--
作者：
Zhou,XY;Wang,Y
材料和方法：药物、化学品和抗体。CPT钠盐（NCS100800）来自NCI。咖啡因和wortmannin购自Sigma Chemical Co.； ATM或ATR （ataxia-and rad3相关蛋白）特异性抗体购自Oncogene Co.； ATM和ATR的底物pase -1（受胰岛素调节的磷酸化热-酸稳定蛋白）购自Stratagene Co.。
MATERIALS AND METHODSDrugs, Chemicals, and Antibodies. CPT sodium salt (NCS100800) was obtained from NCI. Caffeine and wortmannin were purchased from Sigma Chemical Co. Antibodies specific for ATM or ATR (ataxia-and rad3-related protein) were purchased from Oncogene Co. PHAS-1 (phosphorylated heat-and acid-stable protein regulated by insulin), the substrate of ATM and ATR, was purchased from Stratagene Co.