Horizontal cells of the primate retina: Cone specificity without spectral opponency
Horizontal cells of the primate retina: Cone specificity without spectral opponency
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DOI：
10.1126/science.271.5249.656
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发表时间：
1996-02-02
期刊：
影响因子：
56.9
通讯作者：
Smith, VC
中科院分区：
文献类型：
--
作者：
Dacey, DM;Lee, BB;Smith, VC
人类色觉的色彩维度在视网膜中具有神经基础。神经节细胞，视网膜的输出神经元，表现出光谱双折射;它们被某些波长激发，而被其他波长抑制。假设对手电路出现的水平细胞中间神经元和锥光感受器之间的选择性连接敏感的长，中，短波长（L-，M-和S-锥）的生理和解剖特征的水平细胞镶嵌在猕猴锥连接进行了测试。H1水平细胞只接受来自L-和M-视锥的输入，而H2水平细胞接受来自S-视锥的强输入和来自L-和M-视锥的弱输入。所有的视锥细胞输入信号都是相同的，并且两种水平细胞类型都缺乏双极性。尽管视锥类型的选择性，水平细胞不能在灵长类动物，包括人类的对手转化的位点。
The chromatic dimensions of human color vision have a neural basis in the retina. Ganglion cells, the output neurons of the retina, exhibit spectral opponency; they are excited by some wavelengths and inhibited by others. The hypothesis that the opponent circuitry emerges from selective connections between horizontal cell interneurons and cone photoreceptors sensitive to long, middle, and short wavelengths (L-, M-, and S-cones) was tested by physiologically and anatomically characterizing cone connections of horizontal cell mosaics in macaque monkeys. H1 horizontal cells received input only from L- and M-cones, whereas H2 horizontal cells received a strong input from S-cones and a weaker input from L- and M-cones. All cone inputs were the same sign, and both horizontal cell types lacked opponency. Despite cone type selectivity, the horizontal cell cannot be the locus of an opponent transformation in primates, including humans.