Development of a unifying theory for mechanical adaptation and maintenance of trabecular bone
Development of a unifying theory for mechanical adaptation and maintenance of trabecular bone
复制标题
DOI：
10.1080/14639220512331330453
复制
发表时间：
2005-05
影响因子：
1.6
通讯作者：
R. Ruimerman;R. Huiskes
中科院分区：
文献类型：
--
作者：
R. Ruimerman;R. Huiskes
小梁骨是一种具有复杂 3D 结构的组织，由支柱和板组成，在称为“建模”的生长过程中获得成熟的形态。在成熟过程中，组织通过局部骨吸收和随后的形成不断更新，这一过程称为“重塑”。这两种代谢活动都是由骨吸收破骨细胞和骨形成成骨细胞执行的。众所周知，骨量和小梁方向适应外力，并且替代的负载条件导致内部组织结构的适应。问题是骨骼如何感知外部载荷的特征，以及如何将它们转化为组织的结构适应。基础过程的时间尺度约为数月甚至数年。这使得骨骼成为一个复杂的研究课题。在本文中，我们讨论了计算机模拟的应用来研究显着的自适应过程。我们描述了过去 15 年中经验模型的发展，这些模型能够从宏观水平到细胞水平预测骨骼对外部负荷的适应，在细胞水平中捕获细胞过程中最重要的关系。最新模型解释了在微观水平上在骨小梁中观察到的形态现象。
Trabecular bone is a tissue with a complex 3D structure, consisting of struts and plates, which attains its mature morphology during growth in a process called ‘modeling’. In maturity, the tissue is renewed continuously by local bone resorption and subsequent formation in a process called ‘remodeling’. Both these metabolic activities are executed by bone-resorbing osteoclastic and bone-forming osteoblastic cells. It is known that bone mass and trabecular orientation are adapted to the external forces and that alternative loading conditions lead to adaptations of the internal tissue architecture. The question is how the characteristics of external loads are sensed in the bone, and how they are translated to structural adaptation of the tissue. The time scale of the underlying processes is on the order of months, or even years. This aspect makes bone a complex research topic. In this paper, we discuss the application of computer simulation to investigate the remarkable adaptive processes. We describe our developments of empirical models in the past 15 years, able to predict bone adaptation to external loads from a macroscopic level towards a cell-based level, in which the most important relationships of the cellular processes are captured. The latest model explains the morphological phenomena observed in trabecular bone at a microscopic level.