Cognitive impairment in incident, untreated Parkinson disease The Norwegian ParkWest Study
Cognitive impairment in incident, untreated Parkinson disease The Norwegian ParkWest Study
复制标题
DOI：
10.1212/01.wnl.0000338632.00552.cb
复制
发表时间：
2009-03-31
期刊：
影响因子：
9.9
通讯作者：
Alves, G.
中科院分区：
文献类型：
--
作者：
Aarsland, D.;Bronnick, K.;Alves, G.
背景：关于早期未接受药物治疗的帕金森病（PD）患者的认知功能障碍知之甚少。本研究的目的是探讨挪威南部和西部未经治疗的PD发病队列中轻度认知功能障碍（MCI）和亚型的比例。在对该地区所有新的PD病例进行广泛搜索后，共招募了196名非痴呆的药物初治患者和201名健康对照受试者，他们完成了一系列的神经心理学测试，包括言语记忆，视觉空间，和注意力执行功能受试者被归类为MCI，如果年龄和教育校正的Z-分数下降1.5标准差低于平均值为至少一个的认知domains.Results：PD组受损的所有神经心理学测试比对照组，但效果的大小是小的。最大的效应量被发现为非文字记忆。共有18.9%的PD患者被归类为MCI，与对照组相比，PD的相对风险为2.1（1.2-3.6）。PD伴和不伴MCI的患者在人口统计学和运动功能方面无显著差异。在PD-MCI患者中，近三分之二的人患有非遗忘型MCI亚型，三分之一的人患有遗忘型MCI亚型。研究结果表明，与对照组相比，早期未经治疗的帕金森病（PD）受试者中认知障碍的比例增加了两倍。这对PD的诊断和管理具有重要意义。神经病学（R）2009;72：1121-1126
Background: Little is known regarding the cognitive impairment in subjects with early, drug-naive Parkinson disease (PD). The aim of this study was to explore the proportion with mild cognitive impairment (MCI) and subtypes in an incidence cohort of untreated PD in Southern and Western Norway.Methods: A total of 196 non-demented, drug-naive patients who were recruited after an extensive search of all new cases of PD in the area and 201 healthy control subjects completed a battery of neuropsychological tests of verbal memory, visuospatial, and attentional-executive functioning. Subjects were classified as MCI if the age- and education-corrected z-score was falling 1.5 standard deviations below the mean for at least one of the cognitive domains.Results: The PD group was more impaired on all neuropsychological tests than controls, but the effect sizes were small. The largest effect size was found for verbal memory. A total of 18.9% of the patients with PD were classified as MCI, with a relative risk of 2.1 (1.2-3.6) in PD compared to the control group. Patients with PD with and without MCI did not differ significantly regarding demographic and motor features. Among PD-MCI patients, nearly two-thirds had a non-amnestic MCI subtype, and one third had an amnestic MCI subtype.The findings demonstrate a twofold increase in the proportion with cognitive impairment in subjects with early, untreated Parkinson disease (PD) compared to controls. This has implications for diagnosis and management of PD. Neurology (R) 2009;72:1121-1126