Mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in a murine lesion model: Potential synergistic effects on virulence
Mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in a murine lesion model: Potential synergistic effects on virulence
复制标题
DOI：
10.1128/iai.64.6.2094-2100.1996
复制
发表时间：
1996-06-01
影响因子：
3.1
通讯作者：
Holt, SC
中科院分区：
文献类型：
--
作者：
Feuille, F;Ebersole, JL;Holt, SC
这些研究确定了由牙周病原体具核梭杆菌和牙龈卟啉单胞菌混合感染引起的小鼠脓肿模型中组织破坏的特征。研究了这种协同作用的细菌间效应、细菌相互作用关系的动力学以及组织破坏所需细菌的特性。用牙龈卟啉单胞菌和F. nucleatum菌株引起不同大小的损伤，作为感染剂量的函数。原发感染F.不同比例的具核菌和牙龈卟啉单胞菌（即，
These studies determined the characteristics of tissue destruction in a murine abscess model elicited by mixed infection with the periodontopathogens Fusobacterium nucleatum and Porphyromonas gingivalis. The interbacterial effects of this synergism, the kinetics of the relationship of the bacterial interaction, and the characteristics of the bacteria required for the tissue destruction were studied. Infection of mice with P. gingivalis and F. nucleatum strains elicited lesions of various sizes as a function of infective dose. Primary infection with F. nucleatum plus P. gingivalis at various ratios (i.e.,