ORCHIDECTOMY AND IMMUNE-RESPONSE .3. EFFECT OF ORCHIDECTOMY ON TUMOR INDUCTION AND TRANSPLANTATION IN MICE
ORCHIDECTOMY AND IMMUNE-RESPONSE .3. EFFECT OF ORCHIDECTOMY ON TUMOR INDUCTION AND TRANSPLANTATION IN MICE
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DOI：
10.1098/rspb.1974.0056
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发表时间：
1974-01-01
期刊：
影响因子：
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通讯作者：
CASTRO, JE
中科院分区：
文献类型：
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作者：
CASTRO, JE
本文研究了Balb C小鼠睾丸切除对非明显激素依赖性肿瘤的诱导和移植的影响。睾丸切除术缩短了皮下注射甲基胆蒽和皮下肉瘤出现之间的时间。在肿瘤移植实验中，当甲氨蝶呤肿瘤细胞（与Balb C小鼠同基因）以腹水形式生长时，以及当相同的细胞作为实体皮下肿瘤生长时，椎间盘切除术赋予轻微但显著的保护作用。保护被a.l.s.的管理抵消了。部分被胸腺切除术联合胸腺切除术所消除，这些发现表明细胞介导的免疫改变是保护机制。环磷酰胺治疗与睾丸切除术的组合增加了单独睾丸切除术的抗肿瘤效果。相反，胸腺切除术加速了AKR小鼠自发性白血病的出现，这是已知的胸腺依赖性。其解释可能是胸腺切除术通过引起胸腺肥大增加了恶性转化风险的细胞数量。有人建议，癌症的内分泌治疗的一些有益效果可能是由于宿主免疫力的改变，因此，应用范围比单独管理内分泌依赖性肿瘤更广。
The effects of orchidectomy in Balb C mice on the induction and transplantation of tumours which are not obviously hormone dependent were studied. Orchidectomy prolongs the interval between subcutaneous injection of methylcholanthrene and appearance of subcutaneous sarcoma. In tumour transplantation experiments orchidectomy conferred a slight but significant protective effect when meth A tumour cells (which are syngeneic with Balb C mice) were grown in ascitic form and when the same cells grew as a solid subcutaneous tumour protection was increased. Protection was counteracted by administration of a.l.s. and partially abrogated by thymectomy combined with orchidectomy, findings that suggest alteration of cell mediated immunity as the mechanism of protection. Combination of cyclophosphamide treatment with orchidectomy increased the antitumour effect of orchidectomy alone. In contrast orchidectomy accelerates the appearance of spontaneous leukaemia in AKR mice which is known to be thymus dependent. The explanation is probably that orchidectomy, by causing thymic hypertrophy increases the number of cells at risk of malignant transformation. It is suggested that some of the beneficial effects of the endocrine treatments of cancer may result from alteration of host immunity and have therefore, a range of application wider than in the management of endocrine dependent tumours alone.