Detection and clearance of type-specific and phylogenetically related genital human papillomavirus infections in young women in new heterosexual relationships.
Detection and clearance of type-specific and phylogenetically related genital human papillomavirus infections in young women in new heterosexual relationships.
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在新异性恋关系中的年轻女性中检测和清除类型特异性和系统发育相关的生殖器人乳头瘤病毒感染。
DOI：
10.1101/2023.02.24.23286387
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Franco,EduardoL
中科院分区：
文献类型：
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作者：
Arthur,AndrewW;El-Zein,Mariam;Burchell,AnnN;Tellier,Pierre-Paul;Coutlée,Francois;Franco,EduardoL
背景了解人乳头瘤病毒(HPV)感染的自然历史对于制定宫颈癌预防计划至关重要。我们估计了年轻女性中HPV类型特异性感染的检测和清除。方法HPV感染和通过异性行为在夫妇中的传播(HITCH)研究是对502名最近开始异性关系的大学年龄女性的前瞻性队列。我们测试了在24个月的6次临床访问中收集的36种HPV类型的阴道样本。使用RATES和Kaplan-Meier分析，我们以95%的可信区间(CI)估计事件到事件的统计数据，以检测事件感染和清除事件感染和目前基线感染(分别)。我们在女性和HPV水平进行了分析，HPV类型按系统发育相关分组。结果在24个月内，我们在40.4%的女性(CI，33.4%-48.4%)中发现了事件感染。发生亚型1(43.4；CI，33.6-56.4)、2(47.1；CI，39.9-55.5)和3(46.6；CI，37.7-57.7)感染以类似的速度每1000个感染月清除。我们观察到目前基线感染的HPV水平清除率具有相似的同质性。结论我们的分析为宫颈癌预防规划提供了特定类型的感染自然史估计。HPV水平分析没有明确表明高致癌风险亚类2感染比低致癌风险亚类1和3感染持续时间更长。
BackgroundUnderstanding the natural history of human papillomavirus (HPV) infections is essential to cervical cancer prevention planning. We estimated HPV type-specific infection detection and clearance in young women.MethodsThe HPV Infection and Transmission among Couples through Heterosexual activity (HITCH) study is a prospective cohort of 502 college-age women who recently initiated a heterosexual relationship. We tested vaginal samples collected at 6 clinical visits over 24 months for 36 HPV types. Using rates and Kaplan-Meier analysis, we estimated time-to-event statistics with 95% confidence intervals (CIs) for detection of incident infections and clearance of incident and present-at-baseline infections (separately). We conducted analyses at the woman- and HPV-levels, with HPV types grouped by phylogenetic relatedness.ResultsBy 24 months, we detected incident infections in 40.4% (CI, 33.4%–48.4%) of women. Incident subgenus 1 (43.4; CI, 33.6–56.4), 2 (47.1; CI, 39.9–55.5), and 3 (46.6; CI, 37.7–57.7) infections cleared at similar rates per 1000 infection-months. We observed similar homogeny in HPV-level clearance rates among present-at-baseline infections.ConclusionsOur analyses provide type-specific infection natural history estimates for cervical cancer prevention planning. HPV-level analyses did not clearly indicate that high oncogenic risk subgenus 2 infections persist longer than their low oncogenic risk subgenera 1 and 3 counterparts.