Coffee consumption and risk of colorectal cancer: a meta-analysis of case-control studies
Coffee consumption and risk of colorectal cancer: a meta-analysis of case-control studies
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DOI：
10.1007/s10552-010-9623-5
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发表时间：
2010-11-01
影响因子：
2.3
通讯作者：
Tavani, Alessandra
中科院分区：
文献类型：
--
作者：
Galeone, Carlotta;Turati, Federica;Tavani, Alessandra
对咖啡消费和结直肠癌风险的病例对照研究进行了荟萃分析。2010年5月之前发表的24项合格研究被确定，包括14，846例结直肠癌，结肠癌或直肠癌病例。与非/偶尔饮酒者相比，饮酒者的优势比（OR）为0.83（95% CI 0.73-0.95）结直肠，0.93（95% CI 0.81-1.07）结肠和0.98直肠癌（95%CI 0.85-1.13），研究间存在显著异质性;增加1杯/天的相应OR分别为0.94（95%CI 0.91-0.98）、0.95（95%CI 0.92-0.98）和0.97（95%CI 0.95-0.99）。对于最高咖啡饮用者，与非/低饮用者相比，结直肠癌的OR为0.70（95%CI 0.60-0.81），结肠癌为0.75（95%CI 0.64-0.88），直肠癌为0.87（95%CI 0.75-1.00）。这项病例对照研究的荟萃分析结果表明，咖啡消费对结直肠癌风险有中度有利影响。风险降低在研究设计（基于医院vs.基于人群）、地理区域和考虑的各种混杂因素中一致。它可能反映了一种真实的保护，但也部分或主要是由于反向因果关系，即在肠道症状发作后的病例中咖啡消耗量减少。
A meta-analysis of case-control studies on coffee consumption and colorectal cancer risk was conducted. Twenty-four eligible studies published before May 2010 were identified, including a total of 14,846 cases of colorectal, colon or rectal cancer. Compared to non/occasional drinkers, the odds ratios (OR) for drinkers were 0.83 (95% CI 0.73-0.95) for colorectal, 0.93 (95% CI 0.81-1.07) for colon and 0.98 (95% CI 0.85-1.13) for rectal cancer, with significant heterogeneity among studies; the corresponding ORs for the increment of 1 cup/day were 0.94 (95% CI 0.91-0.98), 0.95 (95% CI 0.92-0.98), and 0.97 (95% CI 0.95-0.99). For the highest coffee drinkers, the ORs were 0.70 (95% CI 0.60-0.81) for colorectal cancer, 0.75 (95% CI 0.64-0.88) for colon cancer and 0.87 (95% CI 0.75-1.00) for rectal cancer, when compared to non/low drinkers. The results of this meta-analysis of case-control studies suggest a moderate favorable effect of coffee consumption on colorectal cancer risk. The reduced risk was consistent across study design (hospital vs. population based), geographic area, and various confounding factors considered. It may reflect a real protection but also partly or largely be due to reverse causation, i.e. decreased coffee consumption among cases following the onset of bowel symptoms.