A proposed mechanism for the cardioprotective effect of oestrogen in women: enhanced endothelial nitric oxide release decreases coronary artery reactivity.
A proposed mechanism for the cardioprotective effect of oestrogen in women: enhanced endothelial nitric oxide release decreases coronary artery reactivity.
复制标题
雌激素对女性心脏保护作用的拟议机制：增强内皮一氧化氮释放，降低冠状动脉反应性。
DOI：
10.1111/j.1440-1681.1996.tb02608.x
复制
发表时间：
1996
影响因子：
2.9
通讯作者：
Nelson,MT
中科院分区：
文献类型：
--
作者：
Wellman,GC;Brayden,JE;Nelson,MT
1. During their reproductive years women have a much lower incidence of coronary heart disease than men of similar age. A cardioprotective effect of circulating oestrogen appears to be responsible for this decrease in cardiovascular mortality in women.2. Oestrogen can enhance nitric oxide (NO) production by the vacular endothelium, possibly through enhanced production of the enzyme NO synthase.3. Pressure‐induced constrictions in isolated coronary arteries from rats with physiological circulating levels of oestrogen are reduced compared to oestrogen‐deficient animals. This difference is abolished by endothelial removal or inhibition of NO synthase.4. NO through stimulation of guanylyl cyclase increases levels of the cytosolic second messenger cyclic GMP (cGMP) which activates a cGMP‐dependent protein kinase in vascular smooth muscle cells.5. Potassium currents through calcium‐activated channels in vascular smooth muscle cells are increased in response to NO or upon exposure to cGMP‐dependent protein kinase.6. In rat coronary arteries dilations to NO are reduced by agents which inhibit calcium‐activated potassium channels. NO can also hyperpolarize this tissue, suggesting membrane potential changes are involved in the response to NO.7. We propose that oestrogen increases NO production leading to more negative membrane potentials and decreased calcium entry in coronary vascular smooth muscle cells.
