The relationship of subcortical MRI hyperintensities and brain volume to cognitive function in vascular dementia
The relationship of subcortical MRI hyperintensities and brain volume to cognitive function in vascular dementia
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DOI：
10.1017/s1355617702860027
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发表时间：
2002-09-01
影响因子：
2.6
通讯作者：
Gordon, N
中科院分区：
文献类型：
--
作者：
Cohen, RA;Paul, RH;Gordon, N
MRI结果之间的关系（即，皮质下高信号; SH，全脑体积）和血管性痴呆（VaD）的认知功能障碍。参与者包括24名符合NINDS-AIREN VaD标准（MMSE = 19.9 +/- 4.2）的人，并接受了全面的神经心理学评估和MRI脑成像。皮层下高信号（SH）的体积与执行心理性能密切相关，但与其他认知领域或整体认知功能水平的性能无关。相反，WBV与大多数认知领域（记忆，语言，视觉整合）的整体认知功能和表现密切相关，但与执行心理功能无关。SH未能解释这些VaD患者中明显的整体痴呆或大多数认知领域的损伤，表明深层皮质下白色疾病可能仅间接导致VaD的整体认知功能障碍。WBV作为痴呆症的更强相关性出现，这进一步提出了关于有助于VaD发展的大脑机制的问题。
The relationship between MRI findings (i.e., subcortical hyperintensities; SH, whole brain volume) and the cognitive dysfunction of vascular dementia (VaD) was examined. Participants included 24 persons that met NINDS-AIREN criteria for VaD (MMSE = 19.9 +/- 4.2) and underwent comprehensive neuropsychological assessment and MRI brain imaging. The volume of subcortical hyperintensities (SH) was strongly associated with executive-psychomotor performance, but not with performance across other cognitive domains or global cognitive functional level. Conversely, WBV was strongly associated with global cognitive functioning and performance across most cognitive domains (memory, language, visual integration), but not with executive-psychomotor functioning. The failure of SH to account for either the global dementia evident in these VaD patients or impairments across most cognitive domains suggests that deep subcortical white matter disease may only indirectly contribute to the global cognitive dysfunction of VaD. That WBV emerged as a stronger correlate of dementia raises further questions regarding the cerebral mechanisms that contribute to the development of VaD.