EXPRESSION OF PSEUDOMONAS-AERUGINOSA VIRULENCE GENES REQUIRES CELL-TO-CELL COMMUNICATION
EXPRESSION OF PSEUDOMONAS-AERUGINOSA VIRULENCE GENES REQUIRES CELL-TO-CELL COMMUNICATION
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DOI：
10.1126/science.8493556
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发表时间：
1993-05-21
期刊：
影响因子：
56.9
通讯作者：
IGLEWSKI, BH
中科院分区：
文献类型：
--
作者：
PASSADOR, L;COOK, JM;IGLEWSKI, BH
铜绿假单胞菌是一种机会性人类病原体，在免疫功能低下的宿主和囊性纤维化个体中引起多种感染。弹性蛋白酶是由这种生物体产生的毒力因子之一，它的表达需要转录激活剂LasR。基因融合实验表明，lasI基因是弹性蛋白酶高表达的关键。lasI基因参与了假单胞菌自诱导剂（PAI）扩散分子的合成。PAI为铜绿假单胞菌提供了表达毒力基因所需的细胞间通讯手段，并可能为治疗方法提供靶点。
Pseudomonas aeruginosa is an opportunistic human pathogen that causes a variety of infections in immunocompromised hosts and individuals with cystic fibrosis. Expression of elastase, one of the virulence factors produced by this organism, requires the transcriptional activator LasR. Experiments with gene fusions show that gene lasI is essential for high expression of elastase. The lasI gene is involved in the synthesis of a diffusible molecule termed Pseudomonas autoinducer (PAI). PAI provides P. aeruginosa with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches.