Exosomes from adipose-derived stem cells alleviate neural injury caused by microglia activation via suppressing NF-kB and MAPK pathway
Exosomes from adipose-derived stem cells alleviate neural injury caused by microglia activation via suppressing NF-kB and MAPK pathway
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DOI：
10.1016/j.jneuroim.2019.576996
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发表时间：
2019-09-15
影响因子：
3.3
通讯作者：
Huang, Xiaoxi
中科院分区：
文献类型：
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作者：
Feng, Nianhua;Jia, Yanjun;Huang, Xiaoxi
小胶质细胞的活化在脑损伤后的神经炎症中起着关键作用。来源于脂肪干细胞（adipose derived stem cells，ADSC）的Exosomes具有与ADSC相似的免疫调节作用。我们假设ADSC来源的exosomes（ADSC-exosomes）可以抑制小胶质细胞的活化并预防神经炎症。我们发现ADSC-exosomes可以通过抑制NF-κ B和MAPK通路来抑制小胶质细胞的活化。脂多糖刺激的小胶质细胞中的炎症因子的生产显着下降时，预处理与ADSC外泌体。此外，ADSC-exosomes可以降低活化的小胶质细胞的细胞毒性。这些结果表明，ADSC-exosomes可能是一种有前途的治疗神经损伤的策略。
Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflammation. We found that ADSC-exosomes could inhibit the activation of microglia cells by suppressing NF-kB and MAPK pathway. Production of inflammatory factors in lipopolysaccharide-stimulated microglia cells decreased significantly when pretreated with ADSC-exosomes. Furthermore, ADSC-exosomes could decrease the cytotoxicity of activated microglia. These results revealed that ADSC-exosomes might be a promising strategy for the therapy of neural injury.