Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation
Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation
复制标题
Notch4 通过抑制 TAK1 激活负调节结核分枝杆菌感染的炎症反应
DOI：
10.1093/infdis/jix636
复制
发表时间：
2018
影响因子：
6.4
通讯作者：
Baoxue
中科院分区：
文献类型：
--
作者：
Zheng Ruijuan;Liu Haipeng;Zhou Yilong;Yan Dapeng;Chen Jianxia;Ma Dapeng;Feng Yonghong;Qin Lianhua;Liu Feng;Huang Xiaochen;Wang Jie;Ge;Baoxue
Notch4通过抑制TRAF6和TAK1的活化而负调节结核分枝杆菌感染后的炎症反应。Notch抑制剂治疗可以作为结核病的一种新的干预策略。
Notch4 is a negative regulator of the host inflammatory response againstMycobacterium tuberculosisinfection by inhibiting the activation of TRAF6 and TAK1. Treatment with a Notch inhibitor could serve as a new intervention strategy for tuberculosis.