Epigenetic effects of green tea polyphenols in cancer.
Epigenetic effects of green tea polyphenols in cancer.
复制标题
绿茶多酚在癌症中的表观遗传作用。
DOI：
10.2217/epi.13.57
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发表时间：
2013-12
期刊：
影响因子：
3.8
通讯作者：
Heber D
中科院分区：
文献类型：
--
作者：
Henning SM;Wang P;Carpenter CL;Heber D
表观遗传学描述了基因表达和染色质组织的遗传改变，而不改变DNA序列。DNA的高甲基化和低甲基化都可以影响基因表达和癌发生的多步骤过程。表观遗传变化是可逆的，可以通过饮食干预来靶向。绿色茶（GT）中的生物活性化合物如（-）-表没食子儿茶素没食子酸酯在食管癌、口腔癌、皮肤癌、乳腺癌、肺癌和前列腺癌细胞的研究中显示出改变DNA甲基转移酶活性，这可能有助于GT的化学预防作用。一项人体研究表明，胃癌中CDX 2和BMP-2甲基化的降低与较高的GT消耗相关。这篇综述的目的是总结我们目前对GT改变表观遗传过程的潜力的了解，这可能在化学预防中有用。
Epigenetics describes heritable alterations of gene expression and chromatin organization without changes in DNA sequence. Both hypermethylation and hypomethylation of DNA can affect gene expression and the multistep process of carcinogenesis. Epigenetic changes are reversible and may be targeted by dietary interventions. Bioactive compounds from green tea (GT) such as (–)-epigallocatechin gallate have been shown to alter DNA methyltransferase activity in studies of esophageal, oral, skin, Tregs, lung, breast and prostate cancer cells, which may contribute to the chemopreventive effect of GT. Three out of four mouse model studies have confirmed the inhibitory effect of (–)-epigallocatechin gallate on DNA methylation. A human study demonstrated that decreased methylation of CDX2 and BMP-2 in gastric carcinoma was associated with higher GT consumption. It is the goal of this review to summarize our current knowledge of the potential of GT to alter epigenetic processes, which may be useful in chemoprevention.