DIET AND HISTOLOGIC TYPES OF BENIGN BREAST DISEASE DEFINED BY SUBSEQUENT RISK OF BREAST-CANCER
DIET AND HISTOLOGIC TYPES OF BENIGN BREAST DISEASE DEFINED BY SUBSEQUENT RISK OF BREAST-CANCER
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DOI：
10.1093/oxfordjournals.aje.a115496
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发表时间：
1990-02-01
影响因子：
5
通讯作者：
LABO, T
中科院分区：
文献类型：
--
作者：
HISLOP, TG;BAND, PR;LABO, T
作者在一项病例对照研究中调查了饮食与良性乳腺疾病的组织学类型之间的关系，这些良性乳腺疾病由随后的乳腺癌风险定义，研究对象是1983年至1985年间进入加拿大国家乳腺筛查研究温哥华中心的志愿者。增生性良性乳腺疾病（n= 124）与补充维生素A（服用维生素A者与不服用维生素A者，比值比(OR) = 0.5）和频繁食用绿色蔬菜（频繁食用与罕见食用，OR = 0.3）呈负相关，而严重异型和边缘性原位癌（n= 32）与频繁食用肉类脂肪（频繁食用与罕见食用，OR = 3.2）直接相关，与维生素A或蔬菜食用无关。良性乳腺疾病的组织学类型与随后发生乳腺癌的风险没有增加的关系（n= 274）。讨论了这些发现与乳腺癌病因的关系。
The authors investigated the relation between diet and histologic types of benign breast disease defined by subsequent risk of breast cancer in a case-control study of volunteers who entered the Vancouver Center of the Canadian National Breast Screening Study between 1983 and 1985. Proliferative benign breast disease (n= 124) was inversely associated with vitamin A supplementation (vitamin A user vs. nonuser, odds ratio (OR) = 0.5) and frequent green vegetable consumption (frequent vs. rare consumption, OR = 0.3), whereas severe atypias and borderline carcinoma in situ (n = 32) were directly associated with frequent meat fats consumption (frequent vs. rare consumption, OR = 3.2) with no asso ciation with vitamin A or vegetable consumption. No dietary relations were found for histologic types of benign breast disease at no increased risk for subsequent breast cancer (n= 274). The implications of these findings in relation to the etiology of breast cancer are discussed.