PROTON MR SPECTROSCOPY IN QUANTITATIVE IN-VIVO DETERMINATION OF FAT-CONTENT IN HUMAN LIVER STEATOSIS
PROTON MR SPECTROSCOPY IN QUANTITATIVE IN-VIVO DETERMINATION OF FAT-CONTENT IN HUMAN LIVER STEATOSIS
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DOI：
10.1002/jmri.1880050311
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发表时间：
1995-05-01
期刊：
影响因子：
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通讯作者：
DALLAPALMA, L
中科院分区：
文献类型：
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作者：
LONGO, R;POLLESELLO, P;DALLAPALMA, L
为了证明肝脂肪变性的脂质体积分数可以用体内氢-1磁共振（MR）光谱准确估计，作者开发了一种基于脂肪变性肝标本脂质提取物体外磁共振光谱的校准程序。用校准程序测定的脂质体积分数与组织形态学测量结果和校准的计算机断层扫描（CT）数据进行比较。磁共振光谱测定的脂肪体积分数与CT结果吻合良好，而组织形态测定法低估了肝脏脂肪的数量。结果表明，磁共振光谱法可以无创地测定脂肪变性肝的脂肪体积分数。
To demonstrate that the lipid volume fraction in liver steatosis can be accurately estimated with in vivo hydrogen-1 magnetic resonance (MR) spectroscopy, the authors developed a calibration procedure based on in vitro MR spectroscopy of lipid extracts from steatotic liver specimens. The lipid volume fractions determined with the calibration procedure were compared with the results of histomorphometry and with calibrated computed tomographic (CT) data. The volume fraction of fat determined with MR spectroscopy was in good agreement with the CT results, whereas histomorphometry underestimated the amount of hepatic fat. The results indicate that determination of the fat volume fraction in steatotic liver can be achieved noninvasively with MR spectroscopy.