Biochemical mechanisms of cardiac hypertrophy.
Biochemical mechanisms of cardiac hypertrophy.
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DOI：
10.1146/annurev.ph.49.030187.002533
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发表时间：
1987
影响因子：
18.2
通讯作者：
H. E. Morgan;E. E. Gordon-E.;Y. Kira;B H L Chua;L A Russo;C. J. Peterson;P J McDermott;P A Watson
中科院分区：
文献类型：
--
作者：
H. E. Morgan;E. E. Gordon-E.;Y. Kira;B H L Chua;L A Russo;C. J. Peterson;P J McDermott;P A Watson
成年大鼠和新生猪的快速心脏生长涉及更有效地利用蛋白质合成途径的现有组分和合成新的核糖体和mRNA以增加蛋白质合成的能力。更高的合成效率可以通过拉伸心室壁的机械扰动来诱导，包括在跳动的心脏中增加的心脏功和增加的心室压力发展，以及在停止引流的心脏中增加的主动脉和心室内压力。尚未确定将拉伸与更有效的蛋白质合成联系起来的生化信号。新核糖体的优先合成发生在Langendorff制剂暴露于高主动脉压的前两个小时内，或在正常大鼠注射甲状腺激素后的四个小时内。蛋白质降解速率在肥大心脏中加速或不变，但在Langendorff制剂中被诱导心脏作功或高主动脉压抑制。总的来说，蛋白质合成的能力和效率增加是心脏生长的主要因素。
Rapid cardiac growth in adult rats and neonatal pigs involves more efficient use of existing components of the protein synthesis pathway and synthesis of new ribosomes and mRNA to increase the capacity for protein synthesis. Greater efficiency of synthesis can be induced by mechanical perturbations that stretch the ventricular wall, including increased cardiac work and increased ventricular pressure development in beating hearts, and increased aortic and intraventricular pressure in arrested-drained hearts. The biochemical signal linking stretch to more efficient protein synthesis has not been identified. Preferential synthesis of new ribosomes occurs in the first two hours of exposure of Langendorff preparations to high aortic pressure or within four hours after injection of thyroid hormone into normal rats. The rate of protein degradation is either accelerated or unchanged in hypertrophing hearts but is inhibited by induction of cardiac work or high aortic pressure in Langendorff preparations. Overall, increased capacity for, and efficiency of, protein synthesis are the major factors accounting for cardiac growth.