HormoneBase, a population-level database of steroid hormone levels across vertebrates.

HormoneBase, a population-level database of steroid hormone levels across vertebrates.
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DOI:
10.1038/sdata.2018.97
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发表时间:
2018-05-22
期刊:
影响因子:
9.8
通讯作者:
Williams TD
Williams TD
中科院分区:
综合性期刊2区
文献类型:
--
作者:
Vitousek MN;Johnson MA;Donald JW;Francis CD;Fuxjager MJ;Goymann W;Hau M;Husak JF;Kircher BK;Knapp R;Martin LB;Miller ET;Schoenle LA;Uehling JJ;Williams TD

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激素是生物体功能和灵活性的核心调节因子,介导从早期发育到衰老的多种表型特征。然而,尽管有这些重要的作用,关于激素系统如何以及为什么在物种内和物种间变化的基本问题仍然没有答案。在这里,我们描述了HormoneBase,一个关于循环类固醇激素水平及其在脊椎动物中变化的数据库。该数据库旨在提供自由生活和未操作的成年脊椎动物血浆糖皮质激素(基线和应激诱导)和雄激素的平均值、变异和范围的所有可用数据。HormoneBase(www.HormoneBase.org)目前包括来自476个物种的超过6,580个条目,在1967年至2015年的648份出版物中报告,以及未发表的数据集。这些指标与物种和种群、性别、研究年份和月份、地理坐标、生活史阶段、激素采样方法和潜伏期以及分析技术等数据有关。这种新的资源可用于分析激素系统的功能和进化,以及激素变化与包括表型变异、适合度和物种分布在内的各种过程之间的关系。
Hormones are central regulators of organismal function and flexibility that mediate a diversity of phenotypic traits from early development through senescence. Yet despite these important roles, basic questions about how and why hormone systems vary within and across species remain unanswered. Here we describe HormoneBase, a database of circulating steroid hormone levels and their variation across vertebrates. This database aims to provide all available data on the mean, variation, and range of plasma glucocorticoids (both baseline and stress-induced) and androgens in free-living and un-manipulated adult vertebrates. HormoneBase (www.HormoneBase.org) currently includes >6,580 entries from 476 species, reported in 648 publications from 1967 to 2015, and unpublished datasets. Entries are associated with data on the species and population, sex, year and month of study, geographic coordinates, life history stage, method and latency of hormone sampling, and analysis technique. This novel resource could be used for analyses of the function and evolution of hormone systems, and the relationships between hormonal variation and a variety of processes including phenotypic variation, fitness, and species distributions.
血浆睾丸激素水平的个体变异来源。
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