Photofunctionalizable Hydrogel for Fabricating Volume Optical Diffractive Sensors
Photofunctionalizable Hydrogel for Fabricating Volume Optical Diffractive Sensors
复制标题
DOI：
10.1002/macp.201900228
复制
发表时间：
2019-07-19
影响因子：
2.5
通讯作者：
Gupta, Ruchi
中科院分区：
文献类型：
--
作者：
Pal, Anil Kumar;Labella, Elisabetta;Gupta, Ruchi
由介孔水凝胶制成的体幅光栅对传感是有益的，但由于它们涉及在软材料中创建高纵横比特征，所以制造起来很困难。报道了一种新型的光功能化水凝胶，并证明了它适合制作光栅传感器，其特征长宽比约为3.2。为了制备具有高光学质量、可利用广泛使用的光源图案化的可光功能化水凝胶，合成了一种水溶性光活性单体和敏化剂。随后，通过将光曝光区中产生的游离胺与pH响应性荧光素异硫氰酸酯反应，在大约100微米厚的可光功能化水凝胶膜中制备透射式幅度光栅。在此描述的体积水凝胶光栅被证明适合于作为样本分析物的pH的实时传感。这项工作将对在厚膜水凝胶中制备衍射光学结构产生重大影响，这将在疾病诊断和医疗监测中应用于生物分子传感。
Volume amplitude gratings made of mesoporous hydrogels are beneficial for sensing, but are difficult to fabricate because they involve creating high aspect ratio features in soft materials. A novel photofunctionalizable hydrogel is reported and its suitability for fabricating grating sensors is demonstrated comprising of features with an aspect ratio of approximate to 3.2. To make a photofunctionalizable hydrogel with high optical quality that can be patterned using widely available light sources, a water-soluble photoactive monomer and sensitizer are synthesized. A transmission amplitude grating is subsequently fabricated in a approximate to 100 mu m thick photofunctionalizable hydrogel film by reaction of the free amines generated in the photoexposed regions with pH-responsive fluorescein isothiocyanate. The volume hydrogel grating described herein is shown to be suitable for real-time sensing of pH as an exemplar analyte. This work will have a significant impact on the fabrication of diffractive optical structures in thick films of hydrogels that are highly promising for biomolecular sensing in disease diagnosis and healthcare monitoring.