The effects of closed tracheal suctioning plus volume guarantee on cerebral hemodynamics.

The effects of closed tracheal suctioning plus volume guarantee on cerebral hemodynamics.
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DOI:
10.1038/jp.2011.8
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发表时间:
2011-10
影响因子:
2.9
通讯作者:
Williams, D. K.
Williams, D. K.
中科院分区:
医学3区
文献类型:
--
作者:
Kaiser, J. R.;Gauss, C. H.;Williams, D. K.

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目的比较开放式吸痰(OS)+间歇指令通气(IMV)与封闭式吸痰(CS)+容量保证(VG)对极低出生体重儿(VLBW)平均脑血流速度(CBFv)变化的影响。对75例血压正常、呼吸机能正常的极低出生体重儿(头颅超声正常)在出生后第一周内220次吸痰前、中、后监测平均CBFv、二氧化碳分压(PCO2)和平均动脉压(MABP)。采用多元线性回归分析确定影响吸痰后平均CBFv相对变化幅度的因素(S)。总共有49名接受IMV治疗的极低出生体重儿在2002年7月至2005年5月期间接受了124次OS监测;26名接受VG治疗的极低出生体重儿在2006年1月至2007年7月期间接受了96次CS监测。CS+VG组平均CBFv的平均相对变化幅度明显小于CS+VG组,且与二氧化碳分压和吸气-呼吸机组的相对变化幅度有关。CS+VG与OS+IMV的VLBW患儿平均CBFv的平均相对变化幅度较小。
To compare the effects of open tracheal suctioning (OS) plus intermittent mandatory ventilation (IMV) vs closed tracheal suctioning (CS) plus volume guarantee ventilation (VG) on changes in mean cerebral blood-flow velocity (CBFv) of ventilated very low birth weight (VLBW) infants. A total of 75 normotensive, ventilated VLBW infants (with normal cranial ultrasounds) had monitoring of mean CBFv, PCO2 and mean arterial blood pressure (MABP) before, during and after 220 tracheal suctioning sessions during the first week of life. Multiple linear regression analysis was used to determine the factor(s) influencing the magnitude of relative changes from baseline in mean CBFv after suctioning. In all, 49 VLBW infants receiving IMV had monitoring during 124 OS sessions between July 2002 and May 2005; 26 VLBW infants receiving VG had monitoring during 96 CS sessions between January 2006 and July 2007. The average magnitude of relative changes in mean CBFv was significantly less with CS + VG, and was associated with the magnitude of relative changes in PCO2 and suctioning-ventilator group. The average magnitude of relative changes in mean CBFv was reduced in VLBW infants with CS + VG vs OS + IMV.
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