Expression of MUC1 and MUC2 mucins and relationship with cell proliferative activity in human colorectal neoplasia
Expression of MUC1 and MUC2 mucins and relationship with cell proliferative activity in human colorectal neoplasia
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DOI：
10.1046/j.1440-1827.2001.01291.x
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发表时间：
2001-11-01
影响因子：
2.2
通讯作者：
Yonezawa, S
中科院分区：
文献类型：
--
作者：
Li, AH;Goto, M;Yonezawa, S
我们以前对各种人类肿瘤中MUC 1和MUC 2粘蛋白表达的研究发现，MUC 1表达与不良结局相关，而MUC 2表达与良好结局相关。本文研究了200例大肠腺瘤和58例大肠癌中MUC 1和MUC 2抗原的变化及其与肿瘤上皮细胞增殖活性（Ki-67标记指数）的关系。在200例腺瘤中，我们共分析了400例腺瘤性病变（轻度异型增生，200例病变;中度异型增生，153例病变;重度异型增生，47例病变）。MUC 1在腺癌（24%）和腺瘤伴重度异型增生（4%）中表达，但在腺瘤伴轻度或中度异型增生中不表达。MUC 2在轻度不典型增生腺瘤中的表达率（72%）显著高于中度不典型增生腺瘤（45%）和重度不典型增生腺瘤（47%）以及腺癌（38%; P < 0.0001）。MUC 2阳性的腺瘤中Ki-67标记指数明显低于MUC 2阴性的腺瘤（13.6vs24.2%; P < 0.0001）、中度不典型增生腺瘤中Ki-67标记指数明显低于MUC 2阴性的腺瘤（25.7vs44.4%; P < 0.0001）和腺癌中Ki-67标记指数明显低于MUC 2阴性的腺瘤（32.5vs48.4%; P < 0.05）。总之，我们的研究数据表明，MUC 1表达增加和MUC 2表达减少可能与结直肠肿瘤的恶性转化有关。我们还证实了MUC 2表达的降低，与Ki-67标记的增加相关，可能在结直肠腺瘤性变化的进展中起重要作用。
Our previous studies on MUC1 and MUC2 mucin expression in various human neoplasms have found that MUC1 expression is related with a poor outcome whereas MUC2 expression is related with a favorable outcome. In the present study, we examined the alteration of MUC1 and MUC2 antigens on malignant transformation of colorectal mucosa, and also its relationship with cell proliferative activity (Ki-67 labeling index) of neoplastic epithelial cells in 200 adenomas and 58 carcinomas. In the 200 adenomas, we analyzed a total of 400 adenomatous lesions (mild dysplasia, 200 lesions; moderate dysplasia, 153 lesions; severe dysplasia, 47 lesions). MUC1 was expressed in carcinomas (24%) and adenomas with severe dysplasia (4%), but was not expressed in adenomas with mild or moderate dysplasia. MUC2 was expressed in a significantly greater number of adenomas with mild dysplasia (72%) than in adenomas with moderate dysplasia (45%) or severe dysplasia (47%), as well as in the carcinomas (38%; P < 0.0001). The Ki-67 labeling index was significantly lower in the MUC2-positive cases than in the MUC2-negative cases in the adenomas with mild dysplasia (13.6 vs 24.2%; P < 0.0001) or moderate dysplasia (25.7 vs 44.4%; P < 0.0001), and in the carcinomas (32.5 vs 48.4%; P < 0.05). In conclusion, the data from our study indicate that increased MUC1 expression and reduced MUC2 expression may be related to malignant transformation of colorectal neoplasia. We also demonstrated that decreased MUC2 expression, which is correlated with increased Ki-67 labeling, may play an important role in the progression of colorectal adenomatous change.