Accelerated growth rate induced by neonatal high-protein milk formula is not supported by increased tissue protein synthesis in low-birth-weight piglets.
Accelerated growth rate induced by neonatal high-protein milk formula is not supported by increased tissue protein synthesis in low-birth-weight piglets.
复制标题
新生儿高蛋白牛奶式引起的加速生长速率不受较低的猪群中组织蛋白合成的支持支持。
DOI：
10.1155/2012/545341
复制
发表时间：
2012
影响因子：
2.2
通讯作者：
Floc'h N
中科院分区：
文献类型：
--
作者：
Jamin A;Sève B;Thibault JN;Floc'h N
低出生体重新生儿通常喂食高蛋白配方奶粉以促进追赶生长，通常使用抗生素来预防感染。然而，这种做法对组织蛋白质代谢的影响是未知的。仔猪从2岁到7日龄或28日龄用高蛋白配方饲料喂养，添加或不添加阿莫西林，与正常蛋白配方平行，以确定组织蛋白质代谢的变化。当在出生后第一周早期给予抗生素时，喂养高蛋白配方奶可提高2至28日龄的生长速度。这可以通过当仔猪单独饲喂高蛋白配方时发生腹泻来解释。较高的生长速率与较高的饲料转化率和降低蛋白质合成率在小肠，肌肉和胴体，而蛋白水解酶活性在这些组织中测得的是不变的。总之，高蛋白配方奶粉和抗生素引起的生长速度加快并不受肌肉和胴体蛋白质合成增加的支持。
Low-birth-weight neonates are routinely fed a high-protein formula to promote catch-up growth and antibiotics are usually associated to prevent infection. Yet the effects of such practices on tissue protein metabolism are unknown. Baby pigs were fed from age 2 to 7 or 28 d with high protein formula with or without amoxicillin supplementation, in parallel with normal protein formula, to determine tissue protein metabolism modifications. Feeding high protein formula increased growth rate between 2 and 28 days of age when antibiotic was administered early in the first week of life. This could be explained by the occurrence of diarrhea when piglets were fed the high protein formula alone. Higher growth rate was associated with higher feed conversion and reduced protein synthesis rate in the small intestine, muscle and carcass, whereas proteolytic enzyme activities measured in these tissues were unchanged. In conclusion, accelerated growth rate caused by high protein formula and antibiotics was not supported by increased protein synthesis in muscle and carcass.