Changes of α1-protease inhibitor and secretory leukocyte protease inhibitor levels in gingival crevicular fluid before and after non-surgical periodontal treatment
Changes of α1-protease inhibitor and secretory leukocyte protease inhibitor levels in gingival crevicular fluid before and after non-surgical periodontal treatment
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DOI：
10.1034/j.1601-0825.2003.02884.x
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发表时间：
2003-09-01
期刊：
影响因子：
3.8
通讯作者：
Izumi, Y
中科院分区：
文献类型：
--
作者：
Nakamura-Minami, M;Furuichi, Y;Izumi, Y
目的：α 1蛋白酶抑制剂的可能作用实验设计：分别在洁治和根面平整术（SRP）前、术后2周和4周采集龈沟液（GCF）中的α 1-PI和分泌性白细胞蛋白酶抑制剂（SLPI），观察其对牙周病活动性的预测作用。研究了21例中重度牙周炎患者的41个最初在探诊时流血的的部位。根据4周时是否存在探诊出血（BOP）对部位进行分类。结果：BOP（-）组术后2周、4周及BOP（+）组术后4周α 1-PI均明显下降，而对照组术后2周、4周α 1-PI均明显下降。BOP（+）部位的SLPI在2周时显著增加，而BOP（-）部位的SLPI在两个时间点和BOP（+）部位的4周时均无显著差异。结论：牙周非手术治疗后2周GCF α 1-PI可反映牙周组织的愈合情况。GCF SLPI水平可能受到愈合的影响。
OBJECTIVES: The possible contribution of alpha1-protease inhibitor (alpha 1-PI) and secretory leukocyte protease inhibitor (SLPI) in gingival crevicular fluid (GCF) to predict the periodontal disease activity was evaluated.DESIGN: GCF samples were collected at each site before scaling and root planning (SRP), 2 and 4 weeks after SRP.SUBJECTS AND METHODS: Forty-one sites that initially bled on probing in 21 patients with moderate to severe periodontitis were studied. Sites were classified according to the presence or absence of bleeding on probing (BOP) at 4 weeks. In GCF alpha1-PI and SLPI were determined by enzyme-linked immunosorbent assays.RESULTS: A significant decrease was observed in alpha1-PI at 2 and 4 weeks in BOP(-) sites and at 4 weeks in BOP(+) sites. SLPI significantly increased at 2 weeks in BOP(+) site, while SLPI did not significantly differ at both time points in BOP(-) sites and at 4 weeks in BOP(+) sites. GCF alpha1-PI was significantly less at 2 weeks in BOP(-) than in BOP(+) sites.CONCLUSION: At 2 weeks GCF alpha1-PI may reflect the healing response of the periodontal tissues following non-surgical periodontal treatment. GCF SLPI levels may be influenced by healing.