Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host
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DOI：
10.1016/j.coph.2013.08.006
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发表时间：
2013-12-01
影响因子：
4
通讯作者：
Singh, Nagendra
中科院分区：
文献类型：
--
作者：
Ganapathy, Vadivel;Thangaraju, Muthusamy;Singh, Nagendra
结肠细菌和宿主之间的互利关系已被认识到，但这种关系的分子方面仍然知之甚少。膳食纤维对于这种关系至关重要。膳食纤维细菌发酵产生的短链脂肪酸乙酸酯、丙酸和丁酸是结肠细菌和宿主之间的信使。这些细菌代谢物在结肠中的有益作用包括但不限于抑制炎症和预防癌症。最近的研究已确定质膜转运蛋白 SLC5A8 以及细胞表面受体 GPR109A 和 GPR43 对于结肠中短链脂肪酸的生物学作用至关重要。由宿主基因组编码的这三种蛋白质提供了结肠细菌和宿主之间的分子联系。
The mutually beneficial relationship between colonic bacteria and the host has been recognized but the molecular aspects of the relationship remain poorly understood. Dietary fiber is critical to this relationship. The short-chain fatty acids acetate, propionate and butyrate, generated by bacterial fermentation of dietary fiber, serve as messengers between colonic bacteria and the host. The beneficial effects of these bacterial metabolites in colon include, but are not limited to, suppression of inflammation and prevention of cancer. Recent studies have identified the plasma membrane transporter SLC5A8 and the cell-surface receptors GPR109A and GPR43 as essential for the biologic effects of short-chain fatty acids in colon. These three proteins coded by the host genome provide the molecular link between colonic bacteria and the host.