Pseudoepitheliomatous hyperplasia secondary to cutaneous aspergillus.
Pseudoepitheliomatous hyperplasia secondary to cutaneous aspergillus.
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DOI：
10.1097/00000372-200106000-00011
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发表时间：
2001-06
期刊：
影响因子：
--
通讯作者：
R. Goel;M. Wallace
中科院分区：
文献类型：
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作者：
R. Goel;M. Wallace
皮肤曲霉病通常发生在免疫功能低下的宿主身上，也可能使烧伤创面复杂化。假上皮瘤性增生(PH)是一种继发于包括真菌感染在内的多种刺激的组织学反应。我们描述一例18岁男子，状态岗位烧伤超过70%的总体表面积，皮肤霉菌病的腋下和继发性肺高压。1例继发于原发曲霉菌病的PH在喉部已被描述，但据我们所知，从未在皮肤上被描述过。病变的组织学检查显示不规则的棘皮，真皮内有深深的凹陷。真皮浅层和深层有强烈的炎症反应。真皮中发现了许多真菌形式。特殊染色显示分离的菌丝分叉，形态与曲霉菌一致。因此，我们得出结论，皮肤曲霉病应该包括在PH原因的鉴别诊断中，特别是在有这种感染风险的患者群体中。
Cutaneous aspergillosis commonly occurs in immunocompromised hosts and may also complicate burn wounds. Pseudoepitheliomatous hyperplasia (PH) is a histologic reaction secondary to a wide range of stimuli, including fungal infection. We describe a case of an 18-year-old man, status-post burns over 70% of his total body surface area, with cutaneous aspergillosis of the axilla and secondary PH. A single case of PH secondary to primary aspergillosis has been described in the larynx but, to our knowledge, has never been described cutaneously. Histologic examination of the lesion reveals an irregularly acanthotic epidermis with deep invaginations within the dermis. There is an intense inflammatory reaction within the superficial and deep dermis. Numerous fungal forms are identified within the dermis. Special stains demonstrate septate hyphae with dichotomous branching, which is morphologically consistent with Aspergillus. Therefore, we conclude that cutaneous aspergillosis should be included in the differential diagnosis of causes of PH, especially in a patient population at risk for this infection.