GRANULOMATOUS REACTION TO BRUCHS MEMBRANE IN AGE-RELATED MACULAR DEGENERATION
GRANULOMATOUS REACTION TO BRUCHS MEMBRANE IN AGE-RELATED MACULAR DEGENERATION
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DOI：
10.1001/archopht.1994.01090180111045
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发表时间：
1994-06-01
影响因子：
--
通讯作者：
GREEN, WR
中科院分区：
文献类型：
--
作者：
DASTGHEIB, K;GREEN, WR
本文报告一例新生血管性年龄相关性黄斑变性患者的一只眼睛出现肉芽肿反应的组织病理学特征。在Bruch膜和Bruch膜缺损边缘发现多个多核巨细胞。多核巨细胞似乎参与了布鲁赫膜的破裂，并且与视网膜色素上皮的弥漫性疾病和布鲁赫膜的理化性质的变化一起，可能为年龄相关性黄斑变性中的脉络膜新生血管提供血管生成刺激。
The histopathologic features of a granulomatous reaction in one eye of a patient with neovascular age-related macular degeneration are presented. Multiple multinucleated giant cells were found in intimate association with Bruch's membrane and at the margin of Bruch's membrane defects. Multinucleated giant cells appear to participate in the breakdown of Bruch's membrane and, together with diffuse disease of the retinal pigment epithelium and changes in the physicochemical properties of Bruch's membrane, may provide angiogenic stimulus for choroidal neovascularization in age-related macular degeneration.