Non-Coding RNAs Steering the Senescence-Related Progress, Properties, and Application of Mesenchymal Stem Cells.
Non-Coding RNAs Steering the Senescence-Related Progress, Properties, and Application of Mesenchymal Stem Cells.
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非编码 RNA 引导间充质干细胞衰老相关的进展、特性和应用
DOI：
10.3389/fcell.2021.650431
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发表时间：
2021
影响因子：
5.5
通讯作者：
Zhao Z
中科院分区：
文献类型：
--
作者：
Cai J;Qi H;Yao K;Yao Y;Jing D;Liao W;Zhao Z
几十年来，延缓甚至逆转老龄化进程的渴望从未熄灭。毫无疑问，间充质干细胞(MSCs)具有自我更新和多向分化等非凡能力，理应成为这一主题的焦点。尽管MSCs有几个和蔼可亲的临床特征，但经历衰老一方面会导致与年龄相关的疾病，另一方面会导致妥协甚至适得其反的治疗结果。值得注意的是，越来越多的证据表明，非编码RNA(NcRNAs)可以激活各种调控过程。即使表达略有下降或上升，ncRNA也会对细胞命运产生影响，甚至颠覆细胞的命运。因此，从公理上讲，目前为止发现的引导MSCs衰老的ncRNAs的系统说明是迫切需要的。本文介绍了衰老的一般特性、机制及其与骨髓间充质干细胞的关系，并阐述了ncRNAs在骨髓间充质干细胞细胞衰老中的作用。然后阐明了细胞外小泡中包含的ncRNAs，它将衰老的MSCs与其他细胞以及骨骼系统内外的各种过程联系在一起。最后，我们简要介绍了基于ncRNA的治疗在骨髓间充质干细胞相关领域的临床方法学。希望有一天衰老和间充质干细胞之间的复杂关系会被揭示，我们的工作可能会成为迈向这一未来的重要踏脚石。
The thirst to postpone and even reverse aging progress has never been quenched after all these decades. Unequivocally, mesenchymal stem cells (MSCs), with extraordinary abilities such as self-renewal and multi-directional differentiation, deserve the limelight in this topic. Though having several affable clinical traits, MSCs going through senescence would, on one hand, contribute to age-related diseases and, on the other hand, lead to compromised or even counterproductive therapeutical outcomes. Notably, increasing evidence suggests that non-coding RNAs (ncRNAs) could invigorate various regulatory processes. With even a slight dip or an uptick of expression, ncRNAs would make a dent in or even overturn cellular fate. Thereby, a systematic illustration of ncRNAs identified so far to steer MSCs during senescence is axiomatically an urgent need. In this review, we introduce the general properties and mechanisms of senescence and its relationship with MSCs and illustrate the ncRNAs playing a role in the cellular senescence of MSCs. It is then followed by the elucidation of ncRNAs embodied in extracellular vesicles connecting senescent MSCs with other cells and diversified processes in and beyond the skeletal system. Last, we provide a glimpse into the clinical methodologies of ncRNA-based therapies in MSC-related fields. Hopefully, the intricate relationship between senescence and MSCs will be revealed one day and our work could be a crucial stepping-stone toward that future.
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