Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges.
Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges.
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DOI：
10.1016/j.actbio.2010.06.039
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发表时间：
2011-01
影响因子：
9.7
通讯作者：
Wagner, William R.
中科院分区：
文献类型：
--
作者：
Nelson, Devin M.;Ma, Zuwei;Fujimoto, Kazuro L.;Hashizume, Ryotaro;Wagner, William R.
关键词：
由冠状动脉疾病和心肌梗死(MI)引发的心力衰竭是一种广泛存在的、使人虚弱的疾病，预防疾病进展的选择有限。心肌梗死后心肌内注射生物材料理论上提供了一种减少梗死室壁所承受的应力的方法，这可能以一种积极的方式改变病理重塑过程。此外，生物材料注射提供了同时引入细胞成分和生物活性物质仓库的机会。生物衍生、合成和杂化材料已被应用，以及专门为此目的而设计的材料，尽管最优设计参数，包括降解率和轮廓、可注入性、弹性模数和各种可能的生物活性在很大程度上仍有待阐明。这篇综述试图总结目前越来越多的文献，在有或没有同时给予药物或细胞输送的情况下，生物材料注射被用来改善心肌梗死后的功能结果。迄今为止的文献大体上展示了与生物材料注射疗法有关的急性功能益处，涉及各种动物模型和材料成分。据报道，当细胞或药物制剂被加入到递送系统中时，功能得到了进一步的改善。尽管有这些令人鼓舞的早期结果，但所观察到的功能改善背后的具体机制仍有待充分探索，未来采用假设驱动的材料设计和选择的研究可能会增加这种方法在降低心力衰竭发病率和死亡率方面的潜力。
Heart failure initiated by coronary artery disease and myocardial infarction (MI) is a widespread, debilitating condition for which there are a limited number of options to prevent disease progression. Intramyocardial biomaterial injection following MI theoretically provides a means to reduce the stresses experienced by the infarcted ventricular wall, which may alter the pathological remodeling process in a positive manner. Furthermore, biomaterial injection provides an opportunity to concurrently introduce cellular components and depots of bioactive agents. Biologically-derived, synthetic and hybrid materials have been applied, as well as designed expressly for this purpose, although optimal design parameters, including degradation rate and profile, injectability, elastic modulus, and various possible bioactivities largely remain to be elucidated. This review seeks to summarize the current body of growing literature where biomaterial injection, with and without concurrent pharmaceutical or cellular delivery, has been pursued to improve functional outcomes following MI. The literature to date generally demonstrates acute functional benefits associated with biomaterial injection therapy across a broad variety of animal models and material compositions. Further functional improvements have been reported when cellular or pharmaceutical agents have been incorporated into the delivery system. Despite these encouraging early results, the specific mechanisms behind the observed functional improvements remain to be fully explored and future studies employing hypothesis-driven material design and selection may increase the potential for this approach to alleviate the morbidity and mortality of heart failure.
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DOI：
10.1093/ejcts/15.supplement_1.s12
发表时间：
1999-01-01
影响因子：
3.4
作者：
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DOI：
10.1073/pnas.0602877103
发表时间：
2006-05-23
影响因子：
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作者：
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